Drug-polysaccharide/herb interactions and compatibility rationality of Sijunzi decoction based on comprehensive pharmacokinetic screening for multi-components in rats with spleen deficiency syndrome

Dong, Bangjian; Ma, Ping; Chen, Xiaonan; Peng, Ying; Peng, Chongsheng; Li, Xiaobo

doi:10.1016/j.jep.2022.115871

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Drug-polysaccharide/herb interactions and compatibility rationality of Sijunzi decoction based on comprehensive pharmacokinetic screening for multi-components in rats with spleen deficiency syndrome

Author(s): Bangjian Dong , Ping Ma , Xiaonan Chen , Ying Peng , Chongsheng Peng , Xiaobo Li

Publication date Created: February 2023

Publication date (Print): February 2023

Journal: Journal of Ethnopharmacology

Publisher: Elsevier BV

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Recent pharmaceutical evidence on the compatibility rationality of traditional Chinese medicine

Miaomiao Zhou, Yanlong Hong, Xiao Lin … (2017)

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Ginseng polysaccharides enhanced ginsenoside Rb1 and microbial metabolites exposure through enhancing intestinal absorption and affecting gut microbial metabolism

Bei-Lei Han, Hong Shen, Ting I.N.G. Li … (2018)

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Analysis of the restorative effect of Bu-zhong-yi-qi-tang in the spleen-qi deficiency rat model using (1)H-NMR-based metabonomics.

Xiao-Fen Zheng, Jun-Sheng Tian, Peng Liu … (2014)

Bu-zhong-yi-qi-tang (BT) is a classical formula for the treatment of spleen-qi descending, visceroptosis with hyposplenic qi, uterine prolapse, and rectal prolapse due to chronic diarrhea in traditional Chinese medicine (TCM) and has been identified as an effective drug for the treatment of TCM spleen-qi deficiency in clinical practice. The present study aimed to investigate the restorative effect and the potential mechanisms of Bu-zhong-yi-qi-tang in a rat spleen-qi deficiency model using (1)H-NMR-based metabonomics.