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      No ‘Ultra-Short Feedback Mechanism’ for ACTH

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          Abstract

          The influence of the ACTH concentration in the medium on the spontaneous release of ACTH by isolated pituitary cells or single pituitary halves has been studied in vitro. The ACTH concentration was altered either by increasing the incubation volume or by the addition of ACTH. The ACTH concentration in the medium did not affect the release of endogenous ACTH. Thus, no evidence could be derived for the existence of an ‘ultra-short feedback mechanism’ for ACTH.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1974
          1974
          20 March 2008
          : 16
          : 5-6
          : 364-368
          Affiliations
          Center of Internal Medicine and Pediatrics, Department of Internal Medicine, Endocrinology and Metabolism, University of Ulm, Ulm
          Article
          122582 Neuroendocrinology 1974;16:364–368
          10.1159/000122582
          4375265
          a840d37e-e551-44db-bd96-bc923332e8af
          © 1974 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 15 July 1974
          : 04 September 1974
          Page count
          Pages: 5
          Categories
          Short Communication

          Endocrinology & Diabetes,Neurology,Nutrition & Dietetics,Sexual medicine,Internal medicine,Pharmacology & Pharmaceutical medicine
          Ultra-short feedback mechanism,Isolated pituitary cells,ACTH radioimmunoassay

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