Bladder drug mirabegron exacerbates atherosclerosis through activation of brown fat-mediated lipolysis

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Abstract

Mirabegron (Myrbetriq) is a β3-adrenoreceptor agonist approved for treating overactive bladder syndrome in human patients. This drug can activate brown adipose tissue (BAT) in adult humans and rodents through the β3-adrenoreceptor-mediated sympathetic activation. However, the effect of the mirabegron, approved by the US Food and Drug Administration, on atherosclerosis-related cardiovascular disease is unknown. Here, we show that the clinical dose of mirabegron-induced BAT activation and browning of white adipose tissue (WAT) exacerbate atherosclerotic plaque development. In apolipoprotein E ^−/− ( ApoE ^−/−) and low-density lipoprotein (LDL) receptor ^−/− ( Ldlr ^−/−) mice, oral administration of clinically relevant doses of mirabegron markedly accelerates atherosclerotic plaque growth and instability by a mechanism of increasing plasma levels of both LDL-cholesterol and very LDL-cholesterol remnants. Stimulation of atherosclerotic plaque development by mirabegron is dependent on thermogenesis-triggered lipolysis. Genetic deletion of the critical thermogenesis-dependent protein, uncoupling protein 1, completely abrogates the mirabegron-induced atherosclerosis. Together, our findings suggest that mirabegron may trigger cardiovascular and cerebrovascular diseases in patients who suffer from atherosclerosis.

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Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity.

D. Steinberg, S. Parthasarathy, T E Carew … (1989)

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Record: found
Abstract: found
Article: not found

Characterization of the adipocyte cellular lineage in vivo

Ryan Berry, Matthew S Rodeheffer (2013)

Mature adipocytes are generated through the proliferation and differentiation of precursor cells. Our prior studies identified adipocyte progenitors in white adipose tissue (WAT) as Lin−:CD29+:CD34+:Sca-1+:CD24+ (CD24+) cells that are capable of generating functional WAT 1 . Here, we employ several Cre recombinase mouse models to identify the adipocyte cellular lineage in vivo. While it has been proposed that white adipocytes are derived from endothelial 2 and hematopoietic 3, 4 lineages, we find that neither of these lineages label white adipocytes. However, platelet-derived growth factor receptor α (PdgfRα)-Cre trace labels all white adipocytes. Analysis of WAT from PdgfRα-Cre reporter mice identifies CD24+ and Lin−:CD29+:CD34+:Sca-1+:CD24− (CD24−) cells as adipocyte precursors. We show that CD24+ cells generate the CD24− population in vivo and the CD24− cells express late markers of adipogenesis. From these data we propose a model where the CD24+ adipocyte progenitors become further committed to the adipocyte lineage as CD24 expression is lost, generating CD24− preadipocytes. This characterization of the adipocyte cellular lineage will facilitate study of the mechanisms that regulate WAT formation in vivo and WAT mass expansion in obesity.

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Central neural regulation of brown adipose tissue thermogenesis and energy expenditure.

Shaun F Morrison, Christopher J Madden, Domenico Tupone (2014)

Thermogenesis, the production of heat energy, is the specific, neurally regulated, metabolic function of brown adipose tissue (BAT) and contributes to the maintenance of body temperature during cold exposure and to the elevated core temperature during several behavioral states, including wakefulness, the acute phase response (fever), and stress. BAT energy expenditure requires metabolic fuel availability and contributes to energy balance. This review summarizes the functional organization and neurochemical influences within the CNS networks governing the level of BAT sympathetic nerve activity to produce the thermoregulatory and metabolically driven alterations in BAT thermogenesis and energy expenditure that contribute to overall energy homeostasis. Copyright © 2014 Elsevier Inc. All rights reserved.