Segmental volume reduction using thermal vapour ablation in patients with severe emphysema: 6-month results of the multicentre, parallel-group, open-label, randomised controlled STEP-UP trial.

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Abstract

Lung volume reduction of emphysematous lobes results in clinical improvement for patients with severe emphysema. However, some segments within a lobe are often substantially more diseased than others, thereby warranting a more targeted approach of the emphysematous parts of a lobe. We therefore did a study to assess whether or not selective sequential treatment of the more diseased upper lobe segments with bronchoscopic vapour ablation led to clinical improvement.

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Journal

Journal ID (iso-abbrev): Lancet Respir Med

Title: The Lancet. Respiratory medicine

Publisher: Elsevier BV

ISSN (Electronic): 2213-2619

ISSN (Print): 2213-2600

Publication date (Electronic): Mar 2016

Volume: 4

Issue: 3

Affiliations

[1 ] Department of Pneumology and Critical Care Medicine Thoraxklinik, University of Heidelberg, Heidelberg, Germany; Translational Lung Research Center Heidelberg (TLRCH,) Member of the German Lung Research Foundation (DZL), Heidelberg, Germany. Electronic address: felix.herth@med.uni-heidelberg.dev.

[2 ] Department of Respiratory and Critical Care Medicine, Ludwig-Boltzmann-Institute for COPD and Respiratory Epidemiology, Otto-Wagner-Hospital, Vienna, Austria.

[3 ] The National Institute for Health Research Respiratory Biomedical Research Unit, Royal Brompton & Harefield NHS Foundation Trust and Imperial College, London, UK.

[4 ] Department of Pneumology and Critical Care Medicine Thoraxklinik, University of Heidelberg, Heidelberg, Germany.

[5 ] Medical Clinic of Pneumology, Gemeinschaftskrankenhaus Havelhöhe, Berlin, Germany.

[6 ] Advanced Lung Disease Program, Mater Misericordiae University Hospital, Dublin, Ireland.

[7 ] Department of Respiratory Medicine, Allergology and Sleep Medicine, General Hospital Nuernberg, Nuremberg, Germany; Paracelsus Medical University, Nuremberg, Germany.

[8 ] Pneumology, Charité Campus-Mitte, Berlin, Germany.

[9 ] Lung Transplant Unit, Prince Charles Hospital, Chermside, QLD, Australia.

[10 ] Asklepios-Fachkliniken Munich-Gauting, Comprehensive Pneumology Center Munich, Gauting, Germany.

[11 ] Western Australia Lung Research, Sir Charles Gairdner Hospital, Perth, WA, Australia.

[12 ] Zentrum für Pneumologie, Hemer, Germany.

[13 ] Department for Pulmonary Diseases, AK, Harburg, Hamburg, Germany.

[14 ] Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital and Monash University, Melbourne, VIC, Australia.

Article

Publisher Item ID: S2213-2600(16)00045-X

DOI: 10.1016/S2213-2600(16)00045-X

PubMed ID: 26899390

SO-VID: aa5ac591-35c7-4b7e-9efa-763533514fa5

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