Mechthild Hartmann , MSC 1 , Stefan Kopf , MD 2 , Claudia Kircher , MD 2 , Verena Faude-Lang , MD 1 , 3 , Zdenka Djuric , MD 2 , Florian Augstein 2 , Hans-Christoph Friederich , MD 1 , Meinhard Kieser , PHD 4 , Angelika Bierhaus , PHD 2 , Per M. Humpert , MD 2 , Wolfgang Herzog , MD 1 , Peter P. Nawroth , MD 2
11 April 2012
To determine whether a mindfulness-based stress reduction (MBSR) intervention is effective for reducing psychosocial distress (i.e., depression, psychosocial stress) and the progression of nephropathy (i.e., albuminuria) and for improving the subjective health status of patients with type 2 diabetes.
Patients with type 2 diabetes and microalbuminuria were randomized to a mindfulness-based intervention ( n = 53) or a treatment-as-usual control ( n = 57) group. The study is designed to investigate long-term outcomes over a period of 5 years. We present data up to the first year of follow-up (FU).
At FU, the MBSR group showed lower levels of depression ( d = 0.71) and improved health status ( d = 0.54) compared with the control group. No significant differences in albuminuria were found. Per-protocol analysis also showed higher stress reduction in the intervention group ( d = 0.64).