Association of PDCD1 gene markers with susceptibility to thyroid cancer.

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Abstract

PD-1 receptor is a co-signaling molecule with an important role in regulation of T-lymphocyte activity. Correlation between PD-1 gene (PDCD1) polymorphisms and some immune-related diseases has been reported before. In current study, we aimed to investigate the association of PD-1 polymorphisms at positions +7146 G/A (PD-1.3) and +7785 C/T (PD-1.5), as well as the emerged haplotypes with susceptibility to thyroid carcinoma.

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Author and article information

Journal

Journal ID (iso-abbrev): J. Endocrinol. Invest.

Title: Journal of endocrinological investigation

Publisher: Springer Nature

ISSN (Electronic): 1720-8386

ISSN (Print): 0391-4097

Publication date (Electronic): May 2017

Volume: 40

Issue: 5

Affiliations

[1 ] Cancer Immunology Group, Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

[2 ] Endocrinology and Metabolism Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.

[3 ] Cancer Immunology Group, Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. erfanin@sums.ac.ir.

Article

Publisher Item ID: 10.1007/s40618-016-0579-5

DOI: 10.1007/s40618-016-0579-5

PubMed ID: 27943063

SO-VID: ab28de89-f3d2-41f2-af80-5c1eceaebf9a

History

Keywords: PD-1,Polymorphism,Thyroid cancer

Data availability:

Keywords: PD-1, Polymorphism, Thyroid cancer

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