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      The skin migratory stage of the schistosomulum of Schistosoma mansoni has a surface showing greater permeability and activity in membrane internalisation than other forms of skin or mechanical schistosomula.

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          Abstract

          Skin schistosomula can be prepared by collecting them after isolated mouse skin have been penetrated by cercariae in vitro. The schistosomula can also migrate out of isolated mouse skin penetrated by cercariae in vitro and from mouse skin penetrated by cercariae in vivo. Schistosomula can also be produced from cercariae applied through a syringe or in a vortex. When certain surface properties of the different forms of schistosomula were compared, those migrating from mouse skin penetrated by cercariae in vivo or in vitro had greatly increased permeability to membrane impermeant molecules such as Lucifer yellow and high molecular weight dextrans. These migrating forms also possessed surfaces which showed greatly enhanced uptake into internal membrane vesicles of the dye FM 143, a marker for endocytosis. This greatly enhanced activity and permeability of the surfaces of tissue migrating schistosomula is likely to be of great importance in the adaptation to the new host.

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          Author and article information

          Journal
          Parasitology
          Parasitology
          Cambridge University Press (CUP)
          1469-8161
          0031-1820
          Aug 2015
          : 142
          : 9
          Affiliations
          [1 ] Laboratory of schistosomiasis,Rene Rachou,Fiocuz,1715 Augusto de Lima,Belo Horizonte,30190-002 MG,Brazil.
          [2 ] Depatarmento de Cirurgia,Faculdade de Medicina UFMG,Belo Horizonte,MG,Brazil.
          [3 ] Centre for Open Studies,Glasgow University,Glasgow,UK.
          Article
          S0031182015000335
          10.1017/S0031182015000335
          26028506
          ab376956-ef5b-4765-8d8d-09d450748f3e
          History

          surface membrane,Schistosomula,endocytosis,permeability
          surface membrane, Schistosomula, endocytosis, permeability

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