High-altitude chronic hypoxia ameliorates obesity-induced non-alcoholic fatty liver disease in mice by regulating mitochondrial and AMPK signaling.

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Abstract

High-fat intake induces obesity and non-alcoholic fatty liver disease (NAFLD). However, high-altitude chronic hypoxia might alleviate NAFLD progression through improved mitochondrial function and AMP-activated protein kinase (AMPK) signaling. We hypothesized that high-altitude chronic hypoxia would have protective effects against NAFLD development.

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Author and article information

Journal

Journal ID (iso-abbrev): Life Sci

Title: Life sciences

Publisher: Elsevier BV

ISSN (Electronic): 1879-0631

ISSN (Print): 0024-3205

Publication date (Electronic): Jul 01 2020

Volume: 252

Affiliations

[1 ] Research Center for High Altitude Medicine, Qinghai University Medical College, Xining 810001, PR China; Key Laboratory of High Altitude Medicine (Qinghai University), Ministry of Education, Xining 810001, PR China; Key Laboratory for Application of High Altitude Medicine in Qinghai Province, Xining 810001, PR China; Endocrinology Department, Qinghai Provincial People's Hospital, Xining 810000, PR China.

[2 ] Research Center for High Altitude Medicine, Qinghai University Medical College, Xining 810001, PR China; Key Laboratory of High Altitude Medicine (Qinghai University), Ministry of Education, Xining 810001, PR China; Key Laboratory for Application of High Altitude Medicine in Qinghai Province, Xining 810001, PR China.

[3 ] Research Center for High Altitude Medicine, Qinghai University Medical College, Xining 810001, PR China; Key Laboratory of High Altitude Medicine (Qinghai University), Ministry of Education, Xining 810001, PR China; Key Laboratory for Application of High Altitude Medicine in Qinghai Province, Xining 810001, PR China. Electronic address: baizz@126.com.

[4 ] Research Center for High Altitude Medicine, Qinghai University Medical College, Xining 810001, PR China; Key Laboratory of High Altitude Medicine (Qinghai University), Ministry of Education, Xining 810001, PR China; Key Laboratory for Application of High Altitude Medicine in Qinghai Province, Xining 810001, PR China. Electronic address: geriligao@hotmail.com.

Article

Publisher Item ID: S0024-3205(20)30381-7

DOI: 10.1016/j.lfs.2020.117633

PubMed ID: 32289432

SO-VID: ab3db5a1-03e9-44bb-a494-742f3b41797b

History

Keywords: NAFLD,Chronic hypoxia,Mitochondria,High altitude,Obesity,AMPK

Data availability:

Keywords: NAFLD, Chronic hypoxia, Mitochondria, High altitude, Obesity, AMPK

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