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      A Rare Case of Invasive Keratinizing Squamous Cell Carcinoma of the Foot

      case-report

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          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Lower extremity soft-tissue lesions are frequently encountered in clinical practice. Cellulitis, osteomyelitis, and diabetic foot ulcerations remain the top differentials. The acuity of illness, imaging studies, and deep wound cultures are helpful in most cases. Malignancies are rare but need immediate attention. Hereby, we report a case of a chronic heel wound which on workup was confirmed as cutaneous squamous cell carcinoma (SCC).

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          Invasive squamous cell carcinoma of the skin: defining a high-risk group.

          Jeffrey Gershenwald, Robert T. Mullen, Yan Xing … (2006)
          Unlike its more common non-invasive form, invasive squamous cell carcinoma (SCC) of the skin can be biologically aggressive and is prone to recur. The objectives of this study were to identify relevant clinicopathologic prognostic factors associated with the outcomes of patients with invasive SCC in order to define a high-risk group. We retrospectively reviewed the records of patients with invasive cutaneous SCC of the trunk or extremities who received surgical treatment at a tertiary care cancer center over the past 10 years. We examined the patterns of presentation, all known clinical and histological risk factors for recurrence, and their association with survival. 136 patients were identified, of whom 102 (74%) were male. Patterns of presentation included primary (n = 91), locally recurrent (n = 16), regional nodal (n = 24), and distant (n = 5) disease. Univariate analysis identified poorly differentiated carcinomas (hazard ratio [HR] = 2.92, P = .016), scar carcinomas (HR = 3.12, P = .008), tumor size > 2 cm (HR = 3.79, P = .006), and regional nodal disease (HR = 5.77, P < .0001) as significant risk factors for recurrence or death. On multivariate analysis, however, only regional nodal disease at presentation (HR = 7.64, P < .0001) was found to be significant. Patients with invasive SCCs metastatic to regional nodes constitute a group at high risk for recurrence and death. Such patients should be considered for adjuvant therapy trials.
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            Skin Cancer Concerns in People of Color: Risk Factors and Prevention

            Alpana K Gupta, Mausumi Bharadwaj, Ravi Mehrotra (2016)
            Background: Though people of color (POC) are less likely to become afflicted with skin cancer, they are much more likely to die from it due to delay in detection or presentation. Very often, skin cancer is diagnosed at a more advanced stage in POC, making treatment difficult. The purpose of this research was to improve awareness regarding skin cancers in people of color by providing recommendations to clinicians and the general public for early detection and photo protection preventive measures. Methods: Data on different types of skin cancers were presented to POC. Due to limited research, there are few resources providing insights for evaluating darkly pigmented lesions in POC. Diagnostic features for different types of skin cancers were recorded and various possible risk factors were considered. Results: This study provided directions for the prevention and early detection of skin cancer in POC based on a comprehensive review of available data. Conclusions: The increased morbidity and mortality rate associated with skin cancer in POC is due to lack of awareness, diagnosis at a more advanced stage and socioeconomic barriers hindering access to care. Raising public health concerns for skin cancer prevention strategies for all people, regardless of ethnic background and socioeconomic status, is the key to timely diagnosis and treatment.
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              COVID-19 and clinical mimics. Correct diagnosis is the key to appropriate therapy

              Kamal Sahu, Ajay Kumar Mishra, Kevin Martin … (2020)
              As of 29 April 2020, across the globe, there are 3,216,353 confirmed Coronavirus disease 2019 (COVID-19 disease) with 227,894 deaths. The health care infrastructure of most of the countries is overwhelmed due to the gigantic upsurge of the new cases within a short time period. Most of the beds in the regular wards and critical care units are currently occupied by either people under investigation (PUI) or COVID-19 confirmed cases. We hereby discuss the challenges faced while approaching any case of shortness of breath, or other common upper respiratory symptoms during the current COVID-19 pandemic era.
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                Author and article information

                Journal
                Journal ID (nlm-ta): Int Med Case Rep J
                Journal ID (iso-abbrev): Int Med Case Rep J
                Journal ID (publisher-id): imcrj
                Journal ID (pmc): imcrj
                Title: International Medical Case Reports Journal
                Publisher: Dove
                ISSN (Electronic): 1179-142X
                Publication date (Electronic): 04 June 2021
                Publication date Collection: 2021
                Volume: 14
                Pages: 381-384
                Affiliations
                [1 ]Department of Internal Medicine, Saint Vincent Hospital , Worcester, MA, 01608, USA
                [2 ]Department of Podiatry Medicine, Saint Vincent Hospital , Worcester, MA, 01608, USA
                [3 ]Department of Pathology, Saint Vincent Hospital , Worcester, MA, 01608, USA
                [4 ]Department of Infectious Diseases, Saint Vincent Hospital , Worcester, MA, 01608, USA
                Author notes
                Correspondence: Kamal Kant Sahu Department of Internal Medicine, Saint Vincent Hospital , Worcester, MA,01608, USA Email drkksahu85@gmail.com
                Author information
                http://orcid.org/0000-0002-0382-6882
                Article
                Publisher ID: 304707
                DOI: 10.2147/IMCRJ.S304707
                PMC ID: 8186998
                SO-VID: ac22ad6b-cadb-4b77-97c2-6022dea4fa10
                Copyright © © 2021 Sahu et al.
                License:

                This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License ( http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms ( https://www.dovepress.com/terms.php).

                History
                Date received : 10 February 2021
                Date accepted : 19 May 2021
                Page count
                Figures: 3, References: 13, Pages: 4
                Categories
                Subject: Case Report

                Keywords: squamous cell carcinoma,malignancy,chronic wound
                Data availability:
                Keywords: squamous cell carcinoma, malignancy, chronic wound

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