Chromatographic retention factor log k IAM obtained from immobilized artificial membrane (IAM) HPLC with buffered, aqueous mobile phases and calculated molecular descriptors (molecular weight — log M W ; molar volume — V M ; polar surface area — PSA; total count of nitrogen and oxygen atoms -( N + O); count of freely rotable bonds — FRB; H-bond donor count — HD; H-bond acceptor count — HA; energy of the highest occupied molecular orbital — E HOMO ; energy of the lowest unoccupied orbital — E LUMO ; dipole moment — DM; polarizability — α) obtained for a group of 175 structurally unrelated compounds were tested in order to generate useful models of solutes’ soil-water partition coefficient normalized to organic carbon log K oc . It was established that log k IAM obtained in the conditions described in this study is not sufficient as a sole predictor of the soil-water partition coefficient. Simple, potentially useful models based on log k IAM and a selection of readily available, calculated descriptors and accounting for over 88% of total variability were generated using multiple linear regression (MLR) and artificial neural networks (ANN). The models proposed in the study were tested on a group of 50 compounds with known experimental log K oc values by plotting the calculated vs. experimental values. There is a good close similarity between the calculated and experimental data for both MLR and ANN models for compounds from different chemical families ( R 2 ≥ 0.80, n = 50) which proves the models’ reliability.