A systematic review of multimodal prehabilitation in breast cancer

Abstract

Purpose

Breast cancer is the most prevalent malignancy in women. Prehabilitation may offer improvements in physical and psychological wellbeing among participants prior to treatment. This systematic review aimed to determine the efficacy of prehabilitation in participants diagnosed with breast cancer.

Methods

A systematic review was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Guidelines. Studies exploring the impact of prehabilitation in participants with breast cancer were included. Studies were assessed independently according to pre-eligibility criteria, with data extraction and methodological quality assessed in parallel.

Results

3184 records were identified according to our search criteria, and 14 articles were included. Articles comprised of quantitative randomised controlled trials ( n = 7), quantitative non-randomised studies ( n = 5), a qualitative study ( n = 1), and a mixed-method study ( n = 1). The majority of selected studies completed exercise programs ( n = 4) or had exercise components ( n = 2), with two focusing on upper-limb exercise. Five articles reported complementary and alternative therapies ( n = 5). Two articles reported smoking cessation ( n = 2), with a single study reporting multi-modal prehabilitation ( n = 1). Mostly, prehabilitation improved outcomes including physical function, quality of life, and psychosocial variables ( P < 0.05). The qualitative data identified preferences for multimodal prehabilitation, compared to unimodal with  an interest in receiving support for longer.

Conclusions

Prehabilitation for patients with breast cancer is an emerging research area that appears to improve outcomes, however, ensuring that adequate intervention timeframes, follow-up, and population groups should be considered for future investigations.

Implications for Cancer Survivors

The implementation of prehabilitation interventions for individuals diagnosed with breast cancer should be utilised by multidisciplinary teams to provide holistic care to patients as it has the potential to improve outcomes across the cancer care trajectory.

Supplementary Information

The online version contains supplementary material available at 10.1007/s10549-022-06759-1.