Kusnezosines A-C, three C19-diterpenoid alkaloids with a new skeleton from Aconitum kusnezoffii Reichb. var. gibbiferum.

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Abstract

Kusnezosines A-C (1-3), three C19-diterpenoid alkaloids with a new skeleton which featured an undescribed lactone type D-ring, were isolated from the roots of Aconitum kusnezoffii Reichb. var. gibbiferum. Kusnezosines A-C are the first naturally occurred C19-diterpenoid alkaloids which possessing an unprecedented lactone D ring, this structure was formed by the cleavage of bond between C-15 and C-16 and a successive lactonization. Their structures were established on the basis of comprehensive spectroscopic data analysis. Besides, another 12 known ones were isolated from this plant, analgesic activity tests on the isolated alkaloids were also carried out.

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Journal

Journal ID (iso-abbrev): Fitoterapia

Title: Fitoterapia

Publisher: Elsevier BV

ISSN (Electronic): 1873-6971

ISSN (Print): 0367-326X

Publication date (Electronic): Jul 2020

Volume: 144

Affiliations

[1 ] Laboratory of Chemistry and Biodiversity, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, Sichuan, PR China; Key laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu 610031, Sichuan, PR China.

[2 ] Laboratory of Chemistry and Biodiversity, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, Sichuan, PR China.

[3 ] Laboratory of Chemistry and Biodiversity, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, Sichuan, PR China; Key laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu 610031, Sichuan, PR China. Electronic address: zhouxl@swjtu.edu.cn.

Article

Publisher Item ID: S0367-326X(20)30191-X

DOI: 10.1016/j.fitote.2020.104609

PubMed ID: 32387374

SO-VID: ae6ae091-753a-4626-acaf-12110ad59cb5

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Keywords: Diterpenoid alkaloids,Analgesic activity,Kusnezosines A-C,Lactone D ring,Aconitum kusnezoffii Reichb. var. gibbiferum,Ranunculaceae

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Keywords: Diterpenoid alkaloids, Analgesic activity, Kusnezosines A-C, Lactone D ring, Aconitum kusnezoffii Reichb. var. gibbiferum, Ranunculaceae

Kusnezosines A-C, three C19-diterpenoid alkaloids with a new skeleton from Aconitum kusnezoffii Reichb. var. gibbiferum.

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