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      Antifungal activity of clinical Lactobacillus strains against Candida albicans biofilms: identification of potential probiotic candidates to prevent oral candidiasis.

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          Abstract

          This study isolated Lactobacillus strains from caries-free subjects and evaluated the inhibitory effects directly on three strains of C. albicans, two clinical strains and one reference strain. Thirty Lactobacillus strains were isolated and evaluated for antimicrobial activity against in vitro C. albicans biofilms. L. paracasei 28.4, L. rhamnosus 5.2 and L. fermentum 20.4 isolates exhibited the most significant inhibitory activity against C. albicans. Co-incubation between these microorganisms resulted in deterrence of biofilm development and retardation of hyphal formation. The hindrance of biofilm development was characterized by the downregulated expression of C. albicans biofilm-specific genes (ALS3, HWP1, EFG1 and CPH1). L. paracasei 28.4, L. rhamnosus 5.2 and L. fermentum 20.4 demonstrated the ability to exert antifungal activity through the inhibition of C. albicans biofilms.

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          Author and article information

          Journal
          Biofouling
          Biofouling
          Informa UK Limited
          1029-2454
          0892-7014
          February 2018
          : 34
          : 2
          Affiliations
          [1 ] a Department of Biosciences and Oral Diagnosis, Institute of Science and Technology , UNESP - Univ Estadual Paulista , Sao Jose dos Campos , Brazil.
          [2 ] b Division of Infectious Diseases , Rhode Island Hospital, Alpert Medical School of Brown University , Providence, RI , USA.
          Article
          10.1080/08927014.2018.1425402
          29380647
          af2400a7-8c21-403c-8f72-f48393ede526
          History

          pathogenesis,Biofilm,Candida albicans,Lactobacillus,mycology

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