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      Some nonasymptotic results on resampling in high dimension, I: Confidence regions, II: Multiple tests

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          Abstract

          We study generalized bootstrap confidence regions for the mean of a random vector whose coordinates have an unknown dependency structure. The random vector is supposed to be either Gaussian or to have a symmetric and bounded distribution. The dimensionality of the vector can possibly be much larger than the number of observations and we focus on a nonasymptotic control of the confidence level, following ideas inspired by recent results in learning theory. We consider two approaches, the first based on a concentration principle (valid for a large class of resampling weights) and the second on a resampled quantile, specifically using Rademacher weights. Several intermediate results established in the approach based on concentration principles are of interest in their own right. We also discuss the question of accuracy when using Monte Carlo approximations of the resampled quantities.

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          Resampling-based multiple testing for microarray data analysis

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            Exchangeably Weighted Bootstraps of the General Empirical Process

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              Investigations of dipole localization accuracy in MEG using the bootstrap.

              We describe the use of the nonparametric bootstrap to investigate the accuracy of current dipole localization from magnetoencephalography (MEG) studies of event-related neural activity. The bootstrap is well suited to the analysis of event-related MEG data since the experiments are repeated tens or even hundreds of times and averaged to achieve acceptable signal-to-noise ratios (SNRs). The set of repetitions or epochs can be viewed as a set of independent realizations of the brain's response to the experiment. Bootstrap resamples can be generated by sampling with replacement from these epochs and averaging. In this study, we applied the bootstrap resampling technique to MEG data from somatotopic experimental and simulated data. Four fingers of the right and left hand of a healthy subject were electrically stimulated, and about 400 trials per stimulation were recorded and averaged in order to measure the somatotopic mapping of the fingers in the S1 area of the brain. Based on single-trial recordings for each finger we performed 5000 bootstrap resamples. We reconstructed dipoles from these resampled averages using the Recursively Applied and Projected (RAP)-MUSIC source localization algorithm. We also performed a simulation for two dipolar sources with overlapping time courses embedded in realistic background brain activity generated using the prestimulus segments of the somatotopic data. To find correspondences between multiple sources in each bootstrap, sample dipoles with similar time series and forward fields were assumed to represent the same source. These dipoles were then clustered by a Gaussian Mixture Model (GMM) clustering algorithm using their combined normalized time series and topographies as feature vectors. The mean and standard deviation of the dipole position and the dipole time series in each cluster were computed to provide estimates of the accuracy of the reconstructed source locations and time series.
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                Author and article information

                Journal
                05 December 2007
                2010-01-11
                Article
                10.1214/08-AOS667; 10.1214/08-AOS668
                0712.0775
                af6514e6-d47f-4756-847c-a89398d78f96

                http://arxiv.org/licenses/nonexclusive-distrib/1.0/

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                Custom metadata
                62G15 (Primary) 62G09 (Secondary), 62G10 (Primary) 62G09 (Secondary)
                IMS-AOS-AOS667; IMS-AOS-AOS668
                The Annals of Statistics 38, 1 (2010) 51-99
                Published in at http://dx.doi.org/10.1214/08-AOS667; http://dx.doi.org/10.1214/08-AOS668 the Annals of Statistics (http://www.imstat.org/aos/) by the Institute of Mathematical Statistics (http://www.imstat.org)
                math.ST stat.TH
                ccsd hal-00194145

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