Repurposed antipsychotic chlorpromazine inhibits colorectal cancer and pulmonary metastasis by inducing G2/M cell cycle arrest, apoptosis, and autophagy.

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Abstract

Despite efforts in developing effective therapeutic strategies, colorectal cancer (CRC) remains one of the most prevalent and lethal neoplasms. Repurposing approved drugs is an alluring strategy for developing anticancer agents. Some antipsychotic drugs, including chlorpromazine (CPZ), possess anticancer activities. However, the pharmacological effects of CPZ on CRC have not been clearly established.

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Author and article information

Journal

Journal ID (iso-abbrev): Cancer Chemother Pharmacol

Title: Cancer chemotherapy and pharmacology

Publisher: Springer Science and Business Media LLC

ISSN (Electronic): 1432-0843

ISSN (Print): 0344-5704

Publication date (Electronic): Mar 2022

Volume: 89

Issue: 3

Affiliations

[1 ] Department of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, 610041, China.

[2 ] State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.

[3 ] Key Laboratory of Rehabilitation Medicine in Sichuan Province/Rehabilitation Medicine Research Institute, Chengdu, 610041, China.

[4 ] Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, Chengdu, 610041, China.

[5 ] West China School of Pharmacy, Sichuan University, Chengdu, 610041, China.

[6 ] Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, Sichuan University, Chengdu, 610041, China. 773770248@qq.com.

[7 ] State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China. yiwenzhang@scu.edu.cn.

[8 ] Department of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, 610041, China. yxia4@scu.edu.cn.

[9 ] State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China. yxia4@scu.edu.cn.

[10 ] Key Laboratory of Rehabilitation Medicine in Sichuan Province/Rehabilitation Medicine Research Institute, Chengdu, 610041, China. yxia4@scu.edu.cn.

Article

Publisher Item ID: 10.1007/s00280-021-04386-z

DOI: 10.1007/s00280-021-04386-z

PubMed ID: 35067737

SO-VID: afd6d938-70c1-4edd-b120-48f0ab52d7c8

History

Keywords: Metastasis,Apoptosis,Cell cycle arrest,Chlorpromazine

Data availability:

Keywords: Metastasis, Apoptosis, Cell cycle arrest, Chlorpromazine

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