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      Attenuation of Antidepressant Effects of Ketamine by Opioid Receptor Antagonism

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          Abstract

          In addition to N-methyl-d-aspartate receptor antagonism, ketamine produces opioid system activation. The objective of this study was to determine whether opioid receptor antagonism prior to administration of intravenous ketamine attenuates its acute antidepressant or dissociative effects.

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          Author and article information

          Journal
          American Journal of Psychiatry
          AJP
          American Psychiatric Association Publishing
          0002-953X
          1535-7228
          August 29 2018
          August 29 2018
          : appi.ajp.2018.1
          Affiliations
          [1 ]From the Department of Psychiatry and Behavioral Sciences and the Department of Anesthesiology, Perioperative, and Pain Medicine, Stanford University, Stanford, Calif.; the Department of Psychology, Palo Alto University, Palo Alto, Calif.; and the VA Palo Alto Health Care System, Palo Alto, Calif.
          Article
          10.1176/appi.ajp.2018.18020138
          6395554
          30153752
          © 2018

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