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      Attenuation of Antidepressant Effects of Ketamine by Opioid Receptor Antagonism

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          Abstract

          In addition to N-methyl-d-aspartate receptor antagonism, ketamine produces opioid system activation. The objective of this study was to determine whether opioid receptor antagonism prior to administration of intravenous ketamine attenuates its acute antidepressant or dissociative effects.

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          Author and article information

          Journal
          Title: American Journal of Psychiatry
          Abbreviated Title: AJP
          Publisher: American Psychiatric Association Publishing
          ISSN (Print): 0002-953X
          ISSN (Electronic): 1535-7228
          Publication date Created: August 29 2018
          Publication date (Electronic): August 29 2018
          Page: appi.ajp.2018.1
          Affiliations
          [1 ]From the Department of Psychiatry and Behavioral Sciences and the Department of Anesthesiology, Perioperative, and Pain Medicine, Stanford University, Stanford, Calif.; the Department of Psychology, Palo Alto University, Palo Alto, Calif.; and the VA Palo Alto Health Care System, Palo Alto, Calif.
          Article
          DOI: 10.1176/appi.ajp.2018.18020138
          PMC ID: 6395554
          PubMed ID: 30153752
          SO-VID: afec3cc5-63db-4258-a40b-66387a452257
          Copyright © © 2018
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