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      Diagnostic Accuracy of Copeptin in the Differential Diagnosis of the Polyuria-polydipsia Syndrome: A Prospective Multicenter Study.

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          Abstract

          The polyuria-polydipsia syndrome comprises primary polydipsia (PP) and central and nephrogenic diabetes insipidus (DI). Correctly discriminating these entities is mandatory, given that inadequate treatment causes serious complications. The diagnostic "gold standard" is the water deprivation test with assessment of arginine vasopressin (AVP) activity. However, test interpretation and AVP measurement are challenging.

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          Author and article information

          Journal
          J. Clin. Endocrinol. Metab.
          The Journal of clinical endocrinology and metabolism
          The Endocrine Society
          1945-7197
          0021-972X
          Jun 2015
          : 100
          : 6
          Affiliations
          [1 ] Clinic of Endocrinology, Diabetes and Metabolism, Department of Clinical Research (K.T., N.F., M.C.-C.), University Hospital Basel, CH-4031 Basel, Switzerland; Integrated Research and Treatment Center for Adiposity Diseases (W.F.), Leipzig University Medical Center, 04103 Leipzig, Germany; Division of Endocrinology, Diabetes and Clinical Nutrition (F.K., C.S.), University Hospital Bern-Inselspital, CH-3010 Bern, Switzerland; Department of Internal Medicine (B.Ar.), Spital Rheinfelden, CH-4310 Rheinfelden, Switzerland; University Clinic of Internal Medicine (J.R.), Kantonsspital Baselland, CH-4101 Binningen, Switzerland; Division of Endocrinology, Metabolism and Molecular Medicine and Center for Genetic Medicine (P.K.), Northwestern University, Chicago, Illinois 60611; Department of Internal Medicine I, Endocrine and Diabetes Unit (B.Al.), University Hospital Würzburg, 97080 Würzburg, Germany; Division of Endocrinology, Diabetology and Metabolism, Medical University Clinic (B.M.), Kantonsspital Aarau, CH-5001 Aarau, Switzerland; and Department of Neurology (M.K.), University Hospital Zurich, CH-8091 Zurich, Switzerland.
          Article
          10.1210/jc.2014-4507
          25768671

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