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      Cystic endometriosis in a degenerated sub-serous myoma in a sub-fertile woman: A case report

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          Abstract

          Introduction and importance

          Leiomyoma is the most common gynecologic tumor which may show atypical locations and degenerations. Cystic degeneration is said to be found in 4 % of all degenerations. Endometriosis, the presence of endometrial glands and stroma at extrauterine sites, is a common gynaecological condition seen in 10 % to 15 % of reproductive-age women usually being associated with various degrees of fertility problems.

          Case presentation

          40 years old woman with P1L1A2, with secondary sub-fertility for 5 years, presented with chief complaints of dysmenorrhoea for 1 year initially around the menstrual cycle relieving with analgesics but later not limited to the menstrual cycle and pain not relieving with analgesics since 1 month. The patient underwent fertility-sparing laparoscopic removal avoiding a laparotomy and definitive hysterectomy. Manual morcellation was achieved.

          Clinical discussion

          Cystic degeneration is rare in Leiomyoma although it is the more common gynaecological tumor in women and is associated with endometriosis probably due to retrograde menstruation.

          Conclusions

          Laparoscopic removal of leiomyoma without laparotomy and definitive hysterectomy for a case of cystic endometriosis in a degenerated subserous myoma which to the best of our knowledge according to our search of articles on the relevant topic is the first reported case pertaining to the topic from Nepal.

          Highlights

          • Leiomyoma, being the most common gynecological tumor seen in women, is classified as sub-mucosal, intramural, and sub-serosal according to its origin with the symptoms and signs differing according to the location

          • Leiomyoma degenerations, mostly symptomatic, can sometimes be asymptomatic while subserous leiomyomas are pedunculated and symptoms can be seen due to torsion of the myoma pedicle.

          • The most common degeneration is hyaline degeneration, accounting for about 60% of all degenerating fibroids. Other types of degeneration are myxoid, cystic, calcific, mucoid, red, and fatty degeneration.

          • Cystic degeneration in leiomyoma is rare but is possible.

          • Fertility-sparing laparoscopic removal of tumors avoiding laparotomy also can provide a good outcome in recent years.

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          Most cited references10

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          The SCARE 2020 Guideline: Updating Consensus Surgical CAse REport (SCARE) Guidelines

          The SCARE Guidelines were first published in 2016 and were last updated in 2018. They provide a structure for reporting surgical case reports and are used and endorsed by authors, journal editors and reviewers, in order to increase robustness and transparency in reporting surgical cases. They must be kept up to date in order to drive forwards reporting quality. As such, we have updated these guidelines via a DELPHI consensus exercise.
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            Incidence, aetiology and epidemiology of uterine fibroids.

            Uterine fibroids are the most common benign tumour of the female genital tract. However, their true prevalence is probably under-estimated, as the incidence at histology is more than double the clinical incidence. Recent longitudinal studies have estimated that the lifetime risk of fibroids in a woman over the age of 45 years is more than 60%, with incidence higher in blacks than in whites. The cause of fibroids remains unclear and their biology poorly understood. No single candidate gene has been detected for commonly occurring uterine fibroids. However, the occurrence of rare uterine fibroid syndromes, such as multiple cutaneous and uterine leiomyomatosis, has been traced to the gene that codes for the mitochondrial enzyme, fumarate hydratase. Cytogenetic abnormalities, particularly deletions of chromosome 7, which are found in up to 50% of fibroid specimens, seem to be secondary rather than primary events, and investigations into the role of tumour suppressor genes have yielded conflicting results. The key regulators of fibroid growth are ovarian steroids, both oestrogen and progestogen, growth factors and angiogenesis, and the process of apoptosis. Black race, heredity, nulliparity, obesity, polycystic ovary syndrome, diabetes and hypertension are associated with increased risk of fibroids, and there is emerging evidence that familial predisposition to fibroids is associated with a distinct pattern of clinical and molecular features compared with fibroids in families without this prevalence.
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              Uterine leiomyomas: histopathologic features, MR imaging findings, differential diagnosis, and treatment.

              Leiomyomas are the most common uterine neoplasm and are composed of smooth muscle with varying amounts of fibrous connective tissue. As leiomyomas enlarge, they may outgrow their blood supply, resulting in various types of degeneration: hyaline or myxoid degeneration, calcification, cystic degeneration, and red degeneration. Leiomyomas are classified as submucosal, intramural, or subserosal; the latter may become pedunculated and simulate ovarian neoplasms. Although most leiomyomas are asymptomatic, patients may present with abnormal uterine bleeding, pressure on adjacent organs, pain, infertility, or a palpable abdominalpelvic mass. Magnetic resonance (MR) imaging is the most accurate imaging technique for detection and localization of leiomyomas. On T2-weighted images, nondegenerated leiomyomas appear as well-circumscribed masses of decreased signal intensity; however, cellular leiomyomas can have relatively higher signal intensity on T2-weighted images and demonstrate enhancement on contrast material-enhanced images. Degenerated leiomyomas have variable appearances on T2-weighted images and contrast-enhanced images. The differential diagnosis of leiomyomas includes adenomyosis, solid adnexal mass, focal myometrial contraction, and uterine leiomyosarcoma. For patients with symptoms, medical or surgical treatment may be indicated. MR imaging also has a role in treatment of leiomyomas by assisting in surgical planning and monitoring the response to medical therapy.
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                Author and article information

                Contributors
                Journal
                Int J Surg Case Rep
                Int J Surg Case Rep
                International Journal of Surgery Case Reports
                Elsevier
                2210-2612
                17 March 2023
                April 2023
                17 March 2023
                : 105
                : 107975
                Affiliations
                [a ]BP Koirala Institute of Health Sciences, Nepal
                [b ]Department of Pathology, BP Koirala Institute of Health Sciences, Nepal
                Author notes
                [* ]Corresponding author at: BP Koirala Institute of Health Sciences, Dharan, Nepal. amritbhusal51@ 123456gmail.com
                Article
                S2210-2612(23)00103-7 107975
                10.1016/j.ijscr.2023.107975
                10036934
                36940541
                b0ecf544-e497-4369-b7fd-3af7e849147b
                © 2023 The Authors

                This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

                History
                : 4 October 2022
                : 26 February 2023
                : 1 March 2023
                Categories
                Case Report

                leiomyoma,degeneration,cystic,endometriosis,case report
                leiomyoma, degeneration, cystic, endometriosis, case report

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