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      Performance Characterization of an xy-Stage Applied to Micrometric Laser Direct Writing Lithography

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          Abstract

          This article concerns the characterization of the stability and performance of a motorized stage used in laser direct writing lithography. The system was built from commercial components and commanded by G-code. Measurements use a pseudo-periodic-pattern (PPP) observed by a camera and image processing is based on Fourier transform and phase measurement methods. The results report that the built system has a stability against vibrations determined by peak-valley deviations of 65 nm and 26 nm in the x and y directions, respectively, with a standard deviation of 10 nm in both directions. When the xy-stage is in movement, it works with a resolution of 0.36 µm, which is an acceptable value for most of research and development (R and D) microtechnology developments in which the typical feature size used is in the micrometer range.

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          Most cited references28

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          Fourier-transform method of fringe-pattern analysis for computer-based topography and interferometry

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            Fabrication and multifunction integration of microfluidic chips by femtosecond laser direct writing.

            In the pursuit of modern microfluidic chips with multifunction integration, micronanofabrication techniques play an increasingly important role. Despite the fact that conventional fabrication approaches such as lithography, imprinting and soft lithography have been widely used for the preparation of microfluidic chips, it is still challenging to achieve complex microfluidic chips with multifunction integration. Therefore, novel micronanofabrication approaches that could be used to achieve this end are highly desired. As a powerful 3D processing tool, femtosecond laser fabrication shows great potential to endow general microfluidic chips with multifunctional units. In this review, we briefly introduce the fundamental principles of femtosecond laser micronanofabrication. With the help of laser techniques, both the preparation and functionalization of advanced microfluidic chips are summarized. Finally, the current challenges and future perspective of this dynamic field are discussed based on our own opinion.
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              Trehalose Glycopolymer Resists Allow Direct Writing of Protein Patterns by Electron-Beam Lithography

              Direct-write patterning of multiple proteins on surfaces is of tremendous interest for a myriad of applications. Precise arrangement of different proteins at increasingly smaller dimensions is a fundamental challenge to apply the materials in tissue engineering, diagnostics, proteomics and biosensors. Herein we present a new resist that protects proteins during electron beam exposure and its application in direct-write patterning of multiple proteins. Polymers with pendant trehalose units are shown to effectively cross-link to surfaces as negative resists, while at the same time providing stabilization to proteins during the vacuum and electron beam irradiation steps. In this manner, arbitrary patterns of several different classes of proteins such as enzymes, growth factors and immunoglobulins are realized. Utilizing the high precision alignment capability of electron-beam lithography, surfaces with complex patterns of multiple proteins are successfully generated at the micrometer and nanometer scale without requiring cleanroom conditions.
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                Author and article information

                Contributors
                Role: Academic Editor
                Journal
                Sensors (Basel)
                Sensors (Basel)
                sensors
                Sensors (Basel, Switzerland)
                MDPI
                1424-8220
                31 January 2017
                February 2017
                : 17
                : 2
                : 278
                Affiliations
                [1 ]Grupo de Investigación Electromagnetismo Aplicado, línea Microingeniería, Universidad EAFIT, Medellín 050022, Colombia; jjaram44@ 123456eafit.edu.co
                [2 ]Grupo de Investigación en Automática, Electrónica y Ciencias Computacionales, Línea Sistemas de Control y Robótica, Instituto Tecnológico Metropolitano, ITM, Medellín 050013, Colombia
                [3 ]Grupo de Investigación en Materiales Avanzados y Energía MatyEr, Línea Biomateriales y Electromedicina, Instituto Tecnológico Metropolitano, ITM, Medellín 050013, Colombia; julygaleano@ 123456itm.edu.co
                [4 ]Department of Applied Mechanics, FEMTO-ST Institute, University Bourgogne Franche-Comté, UFC/CNRS/ENSMM/UTBM, Besançon 25000, France; psandoz@ 123456univ-fcomte.fr
                Author notes
                [* ]Correspondence: arturzarzycki@ 123456itm.edu.co ; Tel.: +57-4-460-0727
                Article
                sensors-17-00278
                10.3390/s17020278
                5336059
                28146126
                b131f80e-8273-438b-965f-d3e522ed30b4
                © 2017 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 29 November 2016
                : 03 January 2017
                Categories
                Article

                Biomedical engineering
                laser direct writing,photolithography,microfabrication,g-code,high-resolution positioning,xy-stage

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