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      VEGF receptor signalling - in control of vascular function.

      Nature reviews. Molecular cell biology
      Animals, Embryonic Development, Humans, Neovascularization, Physiologic, Receptors, Vascular Endothelial Growth Factor, metabolism, Signal Transduction, Stem Cells, cytology, Vascular Endothelial Growth Factors

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          Abstract

          Vascular endothelial growth-factor receptors (VEGFRs) regulate the cardiovascular system. VEGFR1 is required for the recruitment of haematopoietic precursors and migration of monocytes and macrophages, whereas VEGFR2 and VEGFR3 are essential for the functions of vascular endothelial and lymphendothelial cells, respectively. Recent insights have shed light onto VEGFR signal transduction and the interplay between different VEGFRs and VEGF co-receptors in development, adult physiology and disease.

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