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      Examining for Cavum Septum Pellucidum and Ventricular Enlargement in Retired Elite-Level Rugby League Players

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          Abstract

          Objective

          A cavum septum pellucidum (CSP) has been reported as a visible brain anomaly in normal individuals as well in some former combat and collision sport athletes. The appearance of CSP with fenestrations and ventricular enlargement are considered associated features of the neuropathological diagnosis of chronic traumatic encephalopathy. The current study examined CSP anatomic features and lateral ventricle size in retired elite rugby league players and controls.

          Methods

          Forty-one retired rugby league players and 41 healthy community controls, similar in age and education, underwent structural MRI scans. CSP grade, CSP length, corpus callosum septal length, and Evans' ratio (for lateral ventricle size) were rated by two of the current study authors. All participants also self-reported concussion exposure histories, depressive symptoms, daytime sleepiness, and impulsivity. They completed a neuropsychological test battery assessing premorbid intellectual functioning, attention, processing speed, language, visuospatial skills, memory, and aspects of executive functioning.

          Results

          The two raters had high agreement for CSP grade (Cohen's κ = 0.80), CSP length [intraclass correlation (ICC) = 0.99], corpus callosum septal length (ICC = 0.73), the CSP/septal ratio (ICC = 0.99), and the Evans' ratio (ICC = 0.75). Twenty-five retired players (61.0%) had an abnormal CSP compared to 17 controls [41.5%; χ ( 1 ,   82 ) 2 = 3.12, p = 0.08, odds ratio = 2.21]. The CSP/septal ratio was larger for retired players than for the controls. The Evans' ratio did not differ between the two groups. In the retired rugby league players ( n = 41), those with normal ( n = 16) and abnormal ( n = 25) CSP grades did not differ across age, age of first exposure to collision sport, years of sport exposure, concussion history, or 23 clinical and cognitive variables.

          Conclusion

          This study revealed a difference in the size of the CSP between retired professional rugby league players and controls. There was no significant difference in the size of the ventricles between the two groups. There were no significant differences between those with vs. without an abnormal CSP on age of first exposure to rugby league, years of exposure to repetitive neurotrauma, number of lifetime concussions, depression, impulsivity, perceived cognitive decline, or on any neuropsychological test.

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          Most cited references93

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          A Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research.

          Intraclass correlation coefficient (ICC) is a widely used reliability index in test-retest, intrarater, and interrater reliability analyses. This article introduces the basic concept of ICC in the content of reliability analysis.
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            Interrater reliability: the kappa statistic

            The kappa statistic is frequently used to test interrater reliability. The importance of rater reliability lies in the fact that it represents the extent to which the data collected in the study are correct representations of the variables measured. Measurement of the extent to which data collectors (raters) assign the same score to the same variable is called interrater reliability. While there have been a variety of methods to measure interrater reliability, traditionally it was measured as percent agreement, calculated as the number of agreement scores divided by the total number of scores. In 1960, Jacob Cohen critiqued use of percent agreement due to its inability to account for chance agreement. He introduced the Cohen’s kappa, developed to account for the possibility that raters actually guess on at least some variables due to uncertainty. Like most correlation statistics, the kappa can range from −1 to +1. While the kappa is one of the most commonly used statistics to test interrater reliability, it has limitations. Judgments about what level of kappa should be acceptable for health research are questioned. Cohen’s suggested interpretation may be too lenient for health related studies because it implies that a score as low as 0.41 might be acceptable. Kappa and percent agreement are compared, and levels for both kappa and percent agreement that should be demanded in healthcare studies are suggested.
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              The structure of negative emotional states: Comparison of the Depression Anxiety Stress Scales (DASS) with the Beck Depression and Anxiety Inventories

              The psychometric properties of the Depression Anxiety Stress Scales (DASS) were evaluated in a normal sample of N = 717 who were also administered the Beck Depression Inventory (BDI) and the Beck Anxiety Inventory (BAI). The DASS was shown to possess satisfactory psychometric properties, and the factor structure was substantiated both by exploratory and confirmatory factor analysis. In comparison to the BDI and BAI, the DASS scales showed greater separation in factor loadings. The DASS Anxiety scale correlated 0.81 with the BAI, and the DASS Depression scale correlated 0.74 with the BDI. Factor analyses suggested that the BDI differs from the DASS Depression scale primarily in that the BDI includes items such as weight loss, insomnia, somatic preoccupation and irritability, which fail to discriminate between depression and other affective states. The factor structure of the combined BDI and BAI items was virtually identical to that reported by Beck for a sample of diagnosed depressed and anxious patients, supporting the view that these clinical states are more severe expressions of the same states that may be discerned in normals. Implications of the results for the conceptualisation of depression, anxiety and tension/stress are considered, and the utility of the DASS scales in discriminating between these constructs is discussed.
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                Author and article information

                Contributors
                Journal
                Front Neurol
                Front Neurol
                Front. Neurol.
                Frontiers in Neurology
                Frontiers Media S.A.
                1664-2295
                06 April 2022
                2022
                : 13
                : 817709
                Affiliations
                [1] 1Priority Research Centre for Stroke and Brain Injury, School of Health Sciences, University of Newcastle , Callaghan, NSW, Australia
                [2] 2Department of Physical Medicine and Rehabilitation, Harvard Medical School , Boston, MA, United States
                [3] 3Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital , Charlestown, MA, United States
                [4] 4Spaulding Research Institute , Charlestown, MA, United States
                [5] 5MassGeneral Hospital for Children Sports Concussion Program , Boston, MA, United States
                [6] 6Home Base, A Red Sox Foundation and Massachusetts General Hospital Program , Charlestown, MA, United States
                [7] 7Providence Veterans Administration Medical Center , Providence, RI, United States
                [8] 8Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University , Providence, RI, United States
                [9] 9Department of Pathology, Northwestern University Feinberg School of Medicine , Chicago, IL, United States
                [10] 10The Florey Institute of Neuroscience and Mental Health , Parkville, VIC, Australia
                [11] 11Priority Research Centre for Stroke and Brain Injury, School of Medicine and Public Health, The University of Newcastle , Callaghan, NSW, Australia
                [12] 12Hunter Medical Research Institute , New Lambton Heights, NSW, Australia
                Author notes

                Edited by: Jehuda Soleman, University Hospital of Basel, Switzerland

                Reviewed by: Scott Lawrence Zuckerman, Vanderbilt University Medical Center, United States; Gary B. Wilkerson, University of Tennessee at Chattanooga, United States; Mark Whiting, Carle Foundation Hospital, United States

                *Correspondence: Peter Stanwell peter.stanwell@ 123456newcastle.edu.au

                This article was submitted to Neurotrauma, a section of the journal Frontiers in Neurology

                Article
                10.3389/fneur.2022.817709
                9044485
                35493804
                b1943d72-1377-44f7-aef6-65485f435f61
                Copyright © 2022 Stanwell, Iverson, Van Patten, Castellani, McCrory and Gardner.

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                : 18 November 2021
                : 11 February 2022
                Page count
                Figures: 1, Tables: 4, Equations: 0, References: 93, Pages: 13, Words: 11449
                Categories
                Neurology
                Original Research

                Neurology
                concussion,traumatic brain injury,magnetic resonance imaging (mri),biomarkers,cavum septum pellucidum,cognition,rugby

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