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      Induction of Ovulation with Human Gonadotrophins: Factors Affecting Ovulation, Pregnancy and Complications

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          Abstract

          All results on 106 women with failure of ovulation who were treated here with gonadotrophins up to November 1968 are summarised. Twenty-three patients failed to ovulate as judged by their excretion of pregnanediol, 39 appeared to ovulate without conceiving and 44 patients conceived and had 56 pregnancies. The dosage of FSH required to induce ovulation varied between 500 and 16,150 IU per monthly course. Adverse results of therapy were nine mild and two severe cases of hyperstimulation syndrome in 203 months with positive pregnanediol responses and there were five pregnancies with triplets or more. An additional case of triplets is included in the appendix. These complications did not appear to be associated with high dosages of FSH or HCG but were associated with elevated excretions of oestriol at the time of giving the ovulating dose of HCG and at the mid-cycle peak and of pregnanediol 8 days after the ovulating dose of HCG. Treatment with FSH which contained little LH was associated with fewer pregnancies with triplets or more but with more abortions than were those with FSH rich in LH. The importance of these results in modifying the method of treatment with gonadotrophins is discussed.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1970
          1970
          21 November 2008
          : 1
          : 1
          : 46-72
          Affiliations
          The United Birmingham Hospitals’ Department of Clinical Endocrinology, Birmingham and Midland Hospital for Women, Birmingham
          Article
          178173 Hormones 1970;1:46–72
          10.1159/000178173
          © 1970 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 27
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