For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
31
views
29
references
 Top references
cited by
45
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      335
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: not found

      Strong Association between Respiratory Viral Infection Early after Hematopoietic Stem Cell Transplantation and the Development of Life-Threatening Acute and Chronic Alloimmune Lung Syndromes

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Alloimmune lung syndromes (allo-LS), including idiopathic pneumonia syndrome, bronchiolitis obliterans syndrome, and bronchiolitis obliterans organizing pneumonia, are severe complications after hematopoietic stem cell transplantation (HSCT). In our cohort of 110 pediatric patients, 30 had allo-LS (27.3%), 18 with ideopathic pneumonia syndrome and 12 with bronchiolitis obliterans syndrome. Multivariate analysis showed that respiratory viral infection early after HSCT is an important predictor for the development of allo-LS ( P <.0001). This was true for all viruses tested. In multivariate analysis, allo-LS was the only predictor for higher mortality ( P = .04). Paradoxically, prolonged administration of immunosuppressive agents because of acute graft-versus-host disease had a protective effect on the development of allo-LS ( P = .004). We hypothesize that early infection of the respiratory tract with a common cold virus makes the lungs a target for alloimmunity.

          Related collections

          Most cited references29

          • Record: found
          • Abstract: found
          • Article: not found

          Respiratory viral infections in adults with hematologic malignancies and human stem cell transplantation recipients: a retrospective study at a major cancer center.

          Nidhi Rohatgi, Issam I Raad, Shubhra Ghosh Dastidar … (2006)
          Community respiratory viruses (CRVs) have been recognized as a potential cause of pneumonia and death among hematopoietic stem cell transplantation (HSCT) recipients and patients with hematologic malignancies. We reviewed the Microbiology Laboratory records dated from July 1, 2000, to June 30, 2002, to identify patients who had respiratory specimens positive for influenza, parainfluenza, respiratory syncytial virus, or picornavirus. We identified 343 infections among patients with underlying hematologic malignancies and HSCT. We collected data on type of disease, age, sex, type of infection, neutrophil and lymphocyte counts, therapy, and outcome. Influenza, parainfluenza, and respiratory syncytial virus accounted for most cases and were approximately equal in frequency. Most infections occurred predominantly among recipients of allogeneic transplants. Infection progressed to pneumonia in 119 patients (35%) and occurred with similar frequency for the 3 viruses. Patients at greatest risk for developing pneumonia included those with leukemia, those aged more than 65 years, and those with severe neutropenia or lymphopenia. Lack of respiratory syncytial virus-directed antiviral therapy (p=0.025) and age (p=0.042) were associated with development of respiratory syncytial virus pneumonia, and an absolute lymphocyte count
          Article 0 comments Cited 129 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            Reference values for residual volume, functional residual capacity and total lung capacity. ATS Workshop on Lung Volume Measurements. Official Statement of The European Respiratory Society.

            P Quanjer, J Stocks (1995)
            Article 0 comments Cited 106 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Respiratory virus infections after stem cell transplantation: a prospective study from the Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation.

              K Pauksen, LAUREN PARKER, C Cordonnier … (2001)
              Community-acquired respiratory virus infections are a cause of mortality after stem cell transplantation (SCT). A prospective study was performed at 37 centers to determine their frequency and importance. Additional cases were also collected to allow the analysis of risk factors for severe infection. Forty episodes were collected in the prospective study and 53 additional episodes through subsequent case collection. The frequency of documented respiratory virus infections was 3.5% among 819 allogeneic and 0.4% among 1154 autologous SCT patients transplanted during the study period. The frequency of lower respiratory tract infections (LRTI) was 2.1% among allogeneic and 0.2% among autologous SCT patients. The mortality within 28 days from diagnosis of a respiratory viral infection was 1.1% among allogeneic SCT while no autologous SCT patient died. The deaths of five patients (0.6%) were directly attributed to a respiratory virus infection (three RSV; two influenza A). On multivariate analysis, lymphocytopenia increased the risk for LRTI (P = 0.008). Lymphocytopenia was also a significant risk factor for LRTI in patients with RSV infections. The overall mortality in RSV infection was 30.4% and the direct RSV-associated mortality was 17.4%. For influenza A virus infection, the corresponding percentages were 23.0% and 15.3%. This prospective study supports the fact that community-acquired respiratory virus infections cause transplant-related mortality after SCT.
              Article 0 comments Cited 105 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Contributors
                A.Birgitta Versluys
                Journal
                Journal ID (nlm-ta): Biol Blood Marrow Transplant
                Journal ID (iso-abbrev): Biol. Blood Marrow Transplant
                Title: Biology of Blood and Marrow Transplantation
                Publisher: Published by Elsevier Inc.
                ISSN (Print): 1083-8791
                ISSN (Electronic): 1523-6536
                Publication date PMC-release: 6 January 2010
                Publication date (Print): June 2010
                Publication date (Electronic): 6 January 2010
                Volume: 16
                Issue: 6
                Pages: 782-791
                Affiliations
                [1 ]Department of Pediatric Hematology/Immunology and Bone Marrow Transplantation, University Medical Center Utrecht/Wilhelmina Children's Hospital, Utrecht, The Netherlands
                [2 ]Department of Virology, Eijkman-Winkler Center, University Medical Center Utrecht, Utrecht, The Netherlands
                [3 ]Laboratory of Medical Microbiology and Immunology, St Elisabeth Hospital, Tilburg, The Netherlands
                [4 ]Department of Paediatric Respiratory Medicine, University Medical Center Utrecht/Wilhelmina Children's Hospital, Utrecht, The Netherlands
                Author notes
                [∗ ]Correspondence and reprint requests: A. B. Versluys, University Medical Center Utrecht/Wilhelmina Children's Hospital, Lundlaan 6, 3584 EA Postbus 85090, 3508 AB, Utrecht, The Netherlands. a.b.versluys@ 123456umcutrecht.nl
                Article
                Publisher ID: S1083-8791(09)01166-5
                DOI: 10.1016/j.bbmt.2009.12.534
                PMC ID: 7110441
                PubMed ID: 20060053
                SO-VID: b2c2986b-aa9a-4927-9519-ca3841302724
                Copyright © Copyright © 2010 Published by Elsevier Inc.
                License:

                Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

                History
                Date received : 29 August 2009
                Date accepted : 29 December 2009
                Categories
                Subject: Article

                Keywords: viral infection,idiopathic pneumonia syndrome,bronchiolitis obliterans,child
                Data availability:
                Keywords: viral infection, idiopathic pneumonia syndrome, bronchiolitis obliterans, child

                Comments

                Comment on this article

                scite_

                Similar content335

                See all similar

                Cited by45

                See all cited by

                Most referenced authors340

                See all reference authors