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      COVID-19 and flu vaccinations among medical residents in a tertiary hospital in Italy: Correspondence

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      a , b
      Human Vaccines & Immunotherapeutics
      Taylor & Francis

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          Abstract

          Dear Editor, we would like to share ideas on the publication “Three-year COVID-19 and flu vaccinations among medical residents in a tertiary hospital in Italy: The threat of acceptance decline in seasonal campaigns. 1 The purpose of the study was to assess vaccination coverage for the COVID-19 second booster dosage and investigate predictors of its acceptance among medical residents (MRs) at the Fondazione Policlinico Universitario “A. Gemelli” IRCCS University Hospital in Italy. The COVID-19 second booster dosage and influenza vaccines were delivered during the study, which lasted from October 4th to December 21st, 2022. The data was examined, and multivariate logistic regressions were run to investigate potential factors of vaccine adherence. The results were compared to the sample of residents enrolled in residency programs at the start of the COVID-19 vaccination campaign. The study comprised a total of 1968 MRs with an average age of 28.97 years. Only 18.80% of individuals received the COVID-19 second booster dose, indicating a lack of coverage. However, practically all individuals chose to receive the COVID-19 and influenza vaccines together, resulting in a similar proportion of influenza vaccination coverage (16.26%). Being a frontline resident, which entails direct involvement in the management of COVID-19 patients and vaccination campaigns, was recognized as the most important predictor of vaccination adherence. The study’s weakness is that it is limited in its generalizability because it only looked at MRs at a single hospital in Italy. The findings may not be applicable to different healthcare settings or demographics. Furthermore, the study did not investigate the reasons for low adherence to the COVID-19 second booster dosage or the reduction in influenza vaccination coverage in the 2022–2023 campaign. Understanding the underlying drivers and challenges to MR vaccine acceptability may provide useful insights for targeted interventions. Furthermore, the study did not investigate the effect of the Omicron variation on vaccination adherence or the efficacy of the COVID-19 second booster dosage in preventing infection or severe disease. These factors could have offered a more thorough examination of the immunization. The primary source of doubt is the erroneous belief that the COVID-19 immunization will virtually surely have an impact on the broader public. 2 The environment and the beginning of the COVID-19 outbreak have an impact on resistance patterns. 3 Since the hesitant pattern evolves over time, the effect of promotion may change with time. If more research is necessary, it should concentrate on identifying and addressing the major causes of vaccination reluctance, such as false information, mistrust, and access problems, as well as developing and evaluating workable solutions to vaccine hesitancy in various contexts. A structural equation model and a thorough analysis of several factors are both helpful for comprehending the problem.

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          Temporal changes in factors associated with COVID-19 vaccine hesitancy and uptake among adults in Hong Kong: Serial cross-sectional surveys

          Summary Background COVID-19 vaccine hesitancy can lead to reduced vaccine uptake and hinder the safe relaxation of other public health measures. This study aims to explore the factors associated with vaccine hesitancy and uptake among adults before and after the implementation of the COVID-19 vaccination program in Hong Kong. Methods Cross-sectional telephone surveys were conducted every four weeks over a nine-month period from November 2020 through July 2021. Target respondents were Hong Kong resident aged 18 or above and recruited by random-digit dialling. In each survey, responses on COVID-19 vaccine hesitancy and COVID-19 vaccine uptake were collected as primary and secondary outcomes, respectively. Data of potentially associated factors, including socio-demographics, chronic medical conditions, perceived risk of COVID-19, perceived personal efficacy in self-protection, confidence in the government's ability to control the pandemic, compliance with social distancing measures, and confidence in COVID-19 vaccines, were also collected. Multivariable logistic regression models were used to examine the factors associated with COVID-19 vaccine hesitancy at different time points. Findings Ten cross-sectional surveys were conducted, including 7411 respondents. The levels of vaccine hesitancy fluctuated over time. From December 2020 to May 2021, the age group with the highest vaccine hesitancy was young adults 18–34y, while the vaccine hesitancy was highest among adults ≥ 65y in June-July 2021 (Fig. 2C). Our regression analyses (Fig. 3) showed that before and at the beginning of the rollout of the mass vaccination program, there was no statistically significant association between chronic medical conditions and vaccine hesitancy. However, two-five months after the program implementation respondents with chronic medical conditions were more likely to be hesitant. From January to June 2021, higher confidence in the government was associated with lower vaccine hesitancy (Fig. 3). Confidence in COVID-19 vaccines was consistently associated with lower vaccine hesitancy at different stages of the program. Interpretation The factors associated with COVID-19 vaccine hesitancy changed over time. This study highlighted the importance to monitor temporal changes in COVID-19 vaccine hesitancy and associated factors, and adjust promotion strategies correspondingly to boost vaccination uptake. Funding Health and Medical Research Fund, Hong Kong.
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            COVID-19 vaccination hesitancy.

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              Three-year COVID-19 and flu vaccinations among medical residents in a tertiary hospital in Italy: The threat of acceptance decline in seasonal campaigns

              ABSTRACT The COVID-19 vaccination campaign in Italy started in December 2020, and, due to the Omicron variant’s emergence, a second booster dose was recommended for high-risk individuals and healthcare workers from July 2022. The aim of the study was to evaluate the vaccination coverages for the COVID-19 second booster dose and to identify predictors of its acceptance within the population of medical residents (MRs) of the Fondazione Policlinico Universitario “A. Gemelli” IRCCS (FPG) University Hospital. The study was conducted at FPG from October 4th to December 21st, 2022, and COVID-19 second booster dose and influenza vaccines were administered. The study analyzed collected data and conducted multivariate logistic regressions to explore potential predictors of vaccination adherence. The analyses performed were compared with the sample enrolled in FPG residency programs at the start of the COVID-19 vaccination campaign. 1968 MRs were involved in the 2022–2023 vaccination campaign (mean age 28.97, SD 3.44), and the second booster dose of COVID-19 vaccination coverage was low (18.80%). Almost all participants opted for co-administration of COVID-19 and influenza vaccinations, leading to a similar rate of influenza vaccination coverage (16.26%). Being a frontline resident, meaning a direct involvement in managing COVID-19 patients and vaccination campaigns, was the main predictor of vaccination adherence (OR 1.72, 95% CI 1.25–2.17). The dropping in influenza vaccination coverage in 2022–2023 and the low adherence to COVID-19 second booster dose among young physicians is concerning, calling for tailored vaccination campaigns and interventions.
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                Author and article information

                Journal
                Hum Vaccin Immunother
                Hum Vaccin Immunother
                Human Vaccines & Immunotherapeutics
                Taylor & Francis
                2164-5515
                2164-554X
                18 October 2023
                2023
                18 October 2023
                : 19
                : 3
                : 2268397
                Affiliations
                [a ]Private Academic Consultant; , Bangkok, Thailand
                [b ]Chandigarh University; , Punjab, India
                Author notes
                CONTACT Rujittika Mungmunpuntipantip rujittika@ 123456gmail.com Private Academic Consultant; , Bangkok, Thailand.
                Author information
                https://orcid.org/0000-0003-0078-7897
                https://orcid.org/0000-0003-1039-3728
                Article
                2268397
                10.1080/21645515.2023.2268397
                10586069
                37849321
                b2cc8959-2a22-48d8-ace4-a205bbf9a01f
                © 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.

                This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License ( http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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                Categories
                Letter to the Editor
                Letter

                Molecular medicine
                Molecular medicine

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