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      The Polycomb complex PRC2 and its mark in life.

      Nature

      Animals, metabolism, chemistry, Repressor Proteins, Polycomb-Group Proteins, genetics, Neoplasms, Methylation, Humans, Histones, Histone-Lysine N-Methyltransferase, Genome, Evolution, Molecular, Chromatin, Cell Differentiation

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          Abstract

          Polycomb group proteins maintain the gene-expression pattern of different cells that is set during early development by regulating chromatin structure. In mammals, two main Polycomb group complexes exist - Polycomb repressive complex 1 (PRC1) and 2 (PRC2). PRC1 compacts chromatin and catalyses the monoubiquitylation of histone H2A. PRC2 also contributes to chromatin compaction, and catalyses the methylation of histone H3 at lysine 27. PRC2 is involved in various biological processes, including differentiation, maintaining cell identity and proliferation, and stem-cell plasticity. Recent studies of PRC2 have expanded our perspectives on its function and regulation, and uncovered a role for non-coding RNA in the recruitment of PRC2 to target genes.

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          Journal
          21248841
          10.1038/nature09784
          3760771

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