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      Bilateral maxillary brown tumors in a patient with primary hyperparathyroidism: Report of a rare entity and review of literature

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          Abstract

          Brown tumors are erosive bony lesions caused by rapid osteoclastic activity and peritrabecular fibrosis due to hyperparathyroidism, resulting in a local destructive phenomenon. The classical “brown tumor” is commonly seen in ends of long bones, the pelvis and ribs. Facial involvement is rare and, when present, usually involves the mandible. We report a case of 60-year-old male with a rare initial presentation of primary hyperparathyroidism with bilateral maxillary brown tumors. The present case represents the third report of the bilateral maxillary brown tumors in a patient with primary hyperparathyroidism. Differential diagnosis is important for the right treatment choice. It should exclude other giant cell lesions that affect the maxillae.

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          Most cited references14

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          Cysts and cystic lesions of the mandible: clinical and radiologic-histopathologic review.

          Many lesions that occur in the mandible have a cystlike radiographic appearance. These lesions are often difficult to differentiate on the basis of their radiographic features alone. Mandibular lesions may be odontogenic or nonodontogenic. Among odontogenic lesions without mineralization, ameloblastomas, odontogenic keratocysts, and dentigerous cysts can all appear as well-defined, unilocular, well-corticated, lucent lesions that are often associated with the crowns of impacted or unerupted teeth. Most radicular cysts appear as round or pear-shaped, unilocular, lucent lesions in the periapical region. Among odontogenic lesions with mineralization, complex odontomas contain multiple masses of dental tissue and compound odontomas contain multiple teeth or toothlike structures. Odontogenic myxomas are characterized by lytic osseous changes of varying size, which may be demarcated and expansile or exhibit ill-defined borders. Nonodontogenic lesions that mimic odontogenic lesions include benign fibro-osseous lesions (conventional or juvenile ossifying fibroma, focal or periapical cemento-osseous dysplasia, florid osseous dysplasia), traumatic bone cyst, lingual salivary gland inclusion defect, central giant cell granuloma, brown tumor of hyperparathyroidism, arteriovenous malformation, and mucoepidermoid carcinoma. The clinical and radiographic features of these mandibular lesions help establish a differential diagnosis, although microscopic tissue evaluation is generally necessary to accurately identify the lesion.
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            Brown tumors of the jaws associated with primary or secondary hyperparathyroidism. A clinical study and review of the literature.

            The aim of this article is to present the development of brown tumors in the jaws as a definite feature of hyperparathyroidism (HPT), whether primary or secondary.
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              Diagnostic Surgical Pathology of the Head and Neck

              DR Gnepp (2001)
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                Author and article information

                Journal
                J Oral Maxillofac Pathol
                JOMFP
                Journal of Oral and Maxillofacial Pathology : JOMFP
                Medknow Publications (India )
                0973-029X
                1998-393X
                Jan-Apr 2011
                : 15
                : 1
                : 56-59
                Affiliations
                Department of Oral and Maxillofacial Pathology, M. R. Ambedkar Dental College, Cline road, Cooke town, Bangalore, India
                [1 ] AECS Maaruti College of Dental Sciences and Research centre, Bangalore, India
                [2 ] MGV’s KBH Dental College and Hospital, Nashik, India
                Author notes
                Address for correspondence: Dr. N Soundarya, Department of Oral and Maxillofacial Pathology, M. R. Ambedkar Dental College, Cline Road, Cooke Town, Bangalore, India E-mail: ndrsoundarya@ 123456yahoo.com
                Article
                JOMFP-15-56
                10.4103/0973-029X.80027
                3125657
                21731279
                b3cc73be-005b-459c-80c5-bff5933febf9
                © Journal of Oral and Maxillofacial Pathology

                This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Categories
                Case Report

                Pathology
                brown tumor,hyperparathyroidism,maxilla
                Pathology
                brown tumor, hyperparathyroidism, maxilla

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