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      Substance P in Rat Corneal and Iridal Nerves: An Ultrastructural Immunohistochemical Study


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          The distribution of substance P (SP) within the nerve fibers of the rat cornea and iris was studied using electron microscopic immunohistochemistry. Numerous SP-immunoreactive fibers were found throughout the corneal and iridal stroma. The most intense staining was found within varicosities containing numerous vesicles. Similar SP-immunoreactive varicosities were found in fibers in close proximity to the iris sphincter and dilator muscles. On account of previous ultrastructural work the SP-containing fibers and varicosities must be assumed to be of trigeminal origin. Additionally, the distribution of SP and calcitonin gene-related peptide (CGRP) in corneal and iridal fibers of rats is similar, suggesting that CGRP and SP are colocalized and may be coreleased from the same varicosities.

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          Author and article information

          Ophthalmic Res
          Ophthalmic Research
          S. Karger AG
          11 December 2009
          : 25
          : 3
          : 192-200
          aDepartment of Morphology The Netherlands Ophthalmic Research Institute, Amsterdam, The Netherlands; bDepartment of Ophthalmology, University of Limburg, Maastricht, The Netherlands
          267291 Ophthalmic Res 1993;25:192–200
          © 1993 S. Karger AG, Basel

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          : 03 December 1992
          : 12 January 1993
          Page count
          Pages: 9
          Original Paper

          Vision sciences,Ophthalmology & Optometry,Pathology
          Cornea,Immunohistochemistry,Calcitonin gene-related peptide,Substance P,Iris


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