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      • Record: found
      • Abstract: found
      • Article: found

      Substance P in Rat Corneal and Iridal Nerves: An Ultrastructural Immunohistochemical Study

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          Abstract

          The distribution of substance P (SP) within the nerve fibers of the rat cornea and iris was studied using electron microscopic immunohistochemistry. Numerous SP-immunoreactive fibers were found throughout the corneal and iridal stroma. The most intense staining was found within varicosities containing numerous vesicles. Similar SP-immunoreactive varicosities were found in fibers in close proximity to the iris sphincter and dilator muscles. On account of previous ultrastructural work the SP-containing fibers and varicosities must be assumed to be of trigeminal origin. Additionally, the distribution of SP and calcitonin gene-related peptide (CGRP) in corneal and iridal fibers of rats is similar, suggesting that CGRP and SP are colocalized and may be coreleased from the same varicosities.

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          Author and article information

          Journal
          Journal ID (publisher-id): ORE
          Journal ID (nlm-ta): Ophthalmic Res
          Journal ID (doi): 10.1159/issn.0030-3747
          Title: Ophthalmic Research
          Publisher: S. Karger AG
          ISSN (Print): 0030-3747
          ISSN (Electronic): 1423-0259
          Publication date Subscription-year: 1993
          Publication date (Print): 1993
          Publication date (Electronic): 11 December 2009
          Volume: 25
          Issue: 3
          Pages: 192-200
          Affiliations
          aDepartment of Morphology The Netherlands Ophthalmic Research Institute, Amsterdam, The Netherlands; bDepartment of Ophthalmology, University of Limburg, Maastricht, The Netherlands
          Article
          Publisher ID: 267291 Other ID: Ophthalmic Res 1993;25:192–200
          DOI: 10.1159/000267291
          PubMed ID: 7687759
          SO-VID: b5002466-4475-41f1-a77f-88f6b5147863
          Copyright © © 1993 S. Karger AG, Basel
          License:

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          Date received : 03 December 1992
          Date accepted : 12 January 1993
          Page count
          Pages: 9
          Categories
          Subject: Original Paper

          ScienceOpen disciplines: Vision sciences,Ophthalmology & Optometry,Pathology
          Keywords: Cornea,Immunohistochemistry,Calcitonin gene-related peptide,Substance P,Iris
          Data availability:
          ScienceOpen disciplines: Vision sciences, Ophthalmology & Optometry, Pathology
          Keywords: Cornea, Immunohistochemistry, Calcitonin gene-related peptide, Substance P, Iris

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