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      Contractile Responses of Aortic and Portal Vein Strips during the Development of DOCA/Salt Hypertension

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          Abstract

          Vascular smooth muscle strips were examined during the development of hypertension in rats treate.d with deoxycorticosterone acetate (DOCA) plus saline to determine if the changes in the contractile responses precede or succeed the increase in blood pressure. After treatment with DOCA/salt for 1,3 and 4 weeks, aortic and portal vein strips were prepared from control and treated rats for studies of cumulative dose-response relationships to noradrenaline (NA) in Krebs’ solutions containing normal (2.5 mM) or low (0.2 and 0.4 mM) concentrations of Ca. 1 week of treatment did not result in any change in blood pressure or in the stress (force/area) developed by the aortic strips in response to NA in normal or low Ca. 3 weeks of treatment caused a significant increase of pressure and the aortic strips developed a significant decrease of stress in response to NA in normal, but not in low Ca. 4 weeks of treatment resulted in a significant increase of pressure and a significant decrease of stress in response to NA in low, as well as in normal, Ca. In contrast to the aortic strips, there was no change in the force induced by NA in the portal vein strips at any time. Thus, the decrease of contractile response in the aortic strips during treatment with DOCA/salt followed the same time course as the increase of arterial pressure and may be a consequence of high blood pressure.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1980
          1980
          19 September 2008
          : 17
          : 6
          : 281-292
          Affiliations
          Department of Pharmacology, Faculty of Medicine, University of British Columbia, Vancouver, B.C.
          Article
          158259 Blood Vessels 1980;17:281–292
          10.1159/000158259
          © 1980 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 12
          Categories
          Research Paper

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