The influence of feeding and gastroprotectant medications on the Factor Xa inhibitory activity of orally administered rivaroxaban in normal dogs.

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Abstract

Rivaroxaban is a new anticoagulant option for dogs, yet its reported oral bioavailability is as low as 60%. The objective of this study was to examine the influence of feeding and gastroprotectant medications on the bioactivity (anti-Xa activity) of rivaroxaban in healthy dogs.

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Journal

Journal ID (iso-abbrev): J Vet Emerg Crit Care (San Antonio)

Title: Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)

Publisher: Wiley

ISSN (Electronic): 1476-4431

ISSN (Print): 1476-4431

Publication date (Electronic): Jan 2021

Volume: 31

Issue: 1

Affiliations

[1 ] Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC.

[2 ] Department of Statistics, North Carolina State University, Raleigh, NC.

[3 ] BluePearl Veterinary Partners, Tampa, FL.

[4 ] Comparative Coagulation Section, College of Veterinary Medicine, Cornell University, Ithaca, NY.

Article

DOI: 10.1111/vec.13019

PubMed ID: 33107158

SO-VID: b63b5234-0edc-43d2-9f06-d691d8f51db4

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Keywords: anticoagulant,antithrombotic,canine direct oral anticoagulants,thromboembolism

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Keywords: anticoagulant, antithrombotic, canine direct oral anticoagulants, thromboembolism

The influence of feeding and gastroprotectant medications on the Factor Xa inhibitory activity of orally administered rivaroxaban in normal dogs.

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