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Elevated monoamine oxidase a levels in the brain: an explanation for the monoamine imbalance of major depression.
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Abstract
The monoamine theory of depression proposes that monoamine levels are lowered, but there is no explanation for how monoamine loss occurs. Monoamine oxidase A (MAO-A) is an enzyme that metabolizes monoamines, such as serotonin, norepinephrine, and dopamine.