1,624
views
0
recommends
+1 Recommend
0 collections
    35
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Exploring the full spectrum of macrophage activation.

      1 ,
      Nature reviews. Immunology
      Springer Science and Business Media LLC

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Macrophages display remarkable plasticity and can change their physiology in response to environmental cues. These changes can give rise to different populations of cells with distinct functions. In this Review we suggest a new grouping of macrophage populations based on three different homeostatic activities - host defence, wound healing and immune regulation. We propose that similarly to primary colours, these three basic macrophage populations can blend into various other 'shades' of activation. We characterize each population and provide examples of macrophages from specific disease states that have the characteristics of one or more of these populations.

          Related collections

          Author and article information

          Journal
          Nat Rev Immunol
          Nature reviews. Immunology
          Springer Science and Business Media LLC
          1474-1741
          1474-1733
          Dec 2008
          : 8
          : 12
          Affiliations
          [1 ] Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742, USA. dmosser@umd.edu
          Article
          nri2448 NIHMS84393
          10.1038/nri2448
          2724991
          19029990
          b77c55d7-6240-46fd-9738-8811cbd1675f
          History

          Comments

          Comment on this article