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      Bio-based production of fuels and industrial chemicals by repurposing antibiotic-producing type I modular polyketide synthases: opportunities and challenges

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      The Journal of Antibiotics

      Springer Nature

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          Abstract

          Complex polyketides comprise a large number of natural products that have broad application in medicine and agriculture. They are produced in bacteria and fungi from large enzyme complexes named type I modular polyketide synthases (PKSs) that are composed of multifunctional polypeptides containing discrete enzymatic domains organized into modules. The modular nature of PKSs has enabled a multitude of efforts to engineer the PKS genes to produce novel polyketides of predicted structure. We have repurposed PKSs to produce a number of short-chain mono- and di-carboxylic acids and ketones that could have applications as fuels or industrial chemicals.

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          Author and article information

          Journal
          The Journal of Antibiotics
          J Antibiot
          Springer Nature
          0021-8820
          1881-1469
          November 16 2016
          November 16 2016
          :
          :
          Article
          10.1038/ja.2016.136
          27847387
          © 2016
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