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Complex polyketides comprise a large number of natural products that have broad application
in medicine and agriculture. They are produced in bacteria and fungi from large enzyme
complexes named type I modular polyketide synthases (PKSs) that are composed of multifunctional
polypeptides containing discrete enzymatic domains organized into modules. The modular
nature of PKSs has enabled a multitude of efforts to engineer the PKS genes to produce
novel polyketides of predicted structure. We have repurposed PKSs to produce a number
of short-chain mono- and di-carboxylic acids and ketones that could have applications
as fuels or industrial chemicals.