Contributors
Ryuta Mizutani:
ORCID: https://orcid.org/0000-0002-5484-4861
Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole:
MethodologyRole: Project administrationRole: ResourcesRole: SoftwareRole: SupervisionRole:
ValidationRole: VisualizationRole: Writing – original draftRole: Writing – review
& editing
Rino Saiga: Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
ValidationRole: VisualizationRole: Writing – review & editing
Yoshiro Yamamoto: Role: Formal analysisRole: ValidationRole: Writing – review & editing
Masayuki Uesugi: Role: InvestigationRole: MethodologyRole: Writing – review & editing
Akihisa Takeuchi: Role: InvestigationRole: MethodologyRole: Writing – review & editing
Kentaro Uesugi: Role: InvestigationRole: MethodologyRole: Writing – review & editing
Yasuko Terada: Role: InvestigationRole: MethodologyRole: Writing – review & editing
Yoshio Suzuki: Role: InvestigationRole: MethodologyRole: Writing – review & editing
Vincent De Andrade: Role: InvestigationRole: MethodologyRole: Writing – review & editing
Francesco De Carlo: Role: InvestigationRole: MethodologyRole: Writing – review & editing
Susumu Takekoshi: Role: ResourcesRole: Writing – review & editing
Chie Inomoto: Role: ResourcesRole: Writing – review & editing
Naoya Nakamura: Role: ResourcesRole: Writing – review & editing
Youta Torii: Role: Funding acquisitionRole: ResourcesRole: Writing – review & editing
Itaru Kushima: Role: Funding acquisitionRole: ResourcesRole: Writing – review & editing
Shuji Iritani: Role: Funding acquisitionRole: ResourcesRole: Writing – review & editing
Norio Ozaki: Role: Funding acquisitionRole: ResourcesRole: Writing – review & editing
Kenichi Oshima: Role: ResourcesRole: Writing – review & editing
Masanari Itokawa: Role: Data curationRole: Project administrationRole: ResourcesRole: SupervisionRole:
Writing – review & editing
Makoto Arai: Role: ResourcesRole: Writing – review & editing
Thiago P. Fernandes: Role: Editor
Journal
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS One
Journal ID (publisher-id): plos
Title:
PLOS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
23
June
2023
Publication date Collection: 2023
Volume: 18
Issue: 6
Electronic Location Identifier: e0287646
Affiliations
[1
]
Department of Bioengineering, Tokai University, Hiratsuka, Kanagawa, Japan
[2
]
Department of Mathematics, Tokai University, Hiratsuka, Kanagawa, Japan
[3
]
Japan Synchrotron Radiation Research Institute (JASRI/SPring-8), Sayo, Hyogo, Japan
[4
]
Photon Factory, High Energy Accelerator Research Organization KEK, Tsukuba, Ibaraki,
Japan
[5
]
Advanced Photon Source, Argonne National Laboratory, Lemont, IL, United States of
America
[6
]
Department of Cell Biology, Tokai University School of Medicine, Isehara, Kanagawa,
Japan
[7
]
Department of Pathology, Tokai University School of Medicine, Isehara, Kanagawa, Japan
[8
]
Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi,
Japan
[9
]
Medical Genomics Center, Nagoya University Hospital, Nagoya, Aichi, Japan
[10
]
Tokyo Metropolitan Matsuzawa Hospital, Setagaya, Tokyo, Japan
[11
]
Tokyo Metropolitan Institute of Medical Science, Setagaya, Tokyo, Japan
Federal University of Paraiba, BRAZIL
Author notes
Competing Interests: I have read the journal’s policy and the authors of this manuscript have the following
competing interests: Masanari Itokawa and Makoto Arai declare a competing interest,
being authors of patents regarding therapeutic use of pyridoxamine for schizophrenia.
The patent title is "Detection and treatment of schizophrenia" (US-2014335517-A1,
JP 5288365, and EP 2189537). This does not alter our adherence to PLOS ONE policies
on sharing data and materials. All other authors declare no competing interest.
[¤]
Current address: Pathophysiology of Mental Disorder, Nagoya University Graduate School
of Medicine, Nagoya, Aichi, Japan
Author information
Article
Publisher ID:
PONE-D-23-07288
DOI: 10.1371/journal.pone.0287646
PMC ID: 10289376
SO-VID: b9e65b48-6a9c-436f-afa2-58c24ccb4110
License:
This is an open access article, free of all copyright, and may be freely reproduced,
distributed, transmitted, modified, built upon, or otherwise used by anyone for any
lawful purpose. The work is made available under the
Creative Commons CC0 public domain dedication.
History
Date
received
: 19
March
2023
Date
accepted
: 11
June
2023
Page count
Figures: 5,
Tables: 0,
Pages: 14
Funding
Funded by:
funder-id http://dx.doi.org/10.13039/100009619, Japan Agency for Medical Research and Development;
Award ID: JP21wm0425007 and JP21dk0307103
Award Recipient
:
Norio Ozaki
Funded by:
funder-id http://dx.doi.org/10.13039/100009619, Japan Agency for Medical Research and Development;
Award ID: JP19km0405216 and JP22tm0424222
Award Recipient
:
Itaru Kushima
Funded by:
funder-id http://dx.doi.org/10.13039/100009619, Japan Agency for Medical Research and Development;
Award ID: JP22wm0425019
Award Recipient
:
Youta Torii
Funded by:
funder-id http://dx.doi.org/10.13039/100009619, Japan Agency for Medical Research and Development;
Award ID: JP22wm0425019
Award Recipient
:
Shuji Iritani
Funded by:
funder-id http://dx.doi.org/10.13039/501100001691, Japan Society for the Promotion of Science;
Award ID: 20K20602 and 21H04815
Award Recipient
:
Norio Ozaki
Funded by:
funder-id http://dx.doi.org/10.13039/501100001691, Japan Society for the Promotion of Science;
Award ID: 21K07543 and 21H00194
Award Recipient
:
Itaru Kushima
This research was supported by the Japan Agency for Medical Research and Development
https://www.amed.go.jp/ (JP21wm0425007 and JP21dk0307103 to NO, JP19km0405216 and JP22tm0424222 to IK, and
JP22wm0425019 to Y Torii and SI) and by the Japan Society for the Promotion of Science
https://www.jsps.go.jp/ (20K20602 and 21H04815 to NO, and 21K07543 and 21H00194 to IK). The funders had no
role in study design, data collection and analysis, decision to publish, or preparation
of the manuscript.
Categories
Subject:
Research Article
Subject:
Medicine and Health Sciences
Subject:
Mental Health and Psychiatry
Subject:
Schizophrenia
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Neurons
Subject:
Neuronal Dendrites
Subject:
Neurites
Subject:
Biology and Life Sciences
Subject:
Neuroscience
Subject:
Cellular Neuroscience
Subject:
Neurons
Subject:
Neuronal Dendrites
Subject:
Neurites
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Neurons
Subject:
Biology and Life Sciences
Subject:
Neuroscience
Subject:
Cellular Neuroscience
Subject:
Neurons
Subject:
Biology and Life Sciences
Subject:
Neuroscience
Subject:
Cognitive Science
Subject:
Cognitive Psychology
Subject:
Perception
Subject:
Sensory Perception
Subject:
Hallucinations
Subject:
Biology and Life Sciences
Subject:
Psychology
Subject:
Cognitive Psychology
Subject:
Perception
Subject:
Sensory Perception
Subject:
Hallucinations
Subject:
Social Sciences
Subject:
Psychology
Subject:
Cognitive Psychology
Subject:
Perception
Subject:
Sensory Perception
Subject:
Hallucinations
Subject:
Biology and Life Sciences
Subject:
Neuroscience
Subject:
Sensory Perception
Subject:
Hallucinations
Subject:
Physical Sciences
Subject:
Mathematics
Subject:
Geometry
Subject:
Curvature
Subject:
Computer and Information Sciences
Subject:
Software Engineering
Subject:
Computer Software
Subject:
Engineering and Technology
Subject:
Software Engineering
Subject:
Computer Software
Subject:
Engineering and Technology
Subject:
Structural Engineering
Subject:
Structural Analysis
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Brain
Subject:
Cingulate Cortex
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Brain
Subject:
Cingulate Cortex
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