Quantitative histomorphometric analysis of halved iliac crest bone biopsies yield comparable ROD diagnosis as full 7.5mm wide samples.

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Abstract

Histomorphometric analysis of a transiliac bone biopsy is the gold standard for the diagnosis of renal osteodystrophy (ROD). This procedure is costly, invasive and usually performed with a trephine with an internal diameter of 7.5 mm. Our objective was to evaluate the accuracy of ROD diagnosis on halved histological bone sections to determine if they are comparable to the standard 7.5 mm samples.

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Journal

Journal ID (iso-abbrev): Bone

Title: Bone

Publisher: Elsevier BV

ISSN (Electronic): 1873-2763

ISSN (Print): 1873-2763

Publication date (Electronic): September 2020

Volume: 138

Affiliations

[1 ] INSERM U1059 and University Hospital, Saint-Etienne, France; Université de Lyon, Lyon, France; Department of Nephrology, University Hospital - Lyon Sud, France. Electronic address: etienne.novel-catin@chu-lyon.fr.

[2 ] Department of Nephrology, University Hospital - Lyon Sud, France. Electronic address: solenne.pelletier@chu-lyon.fr.

[3 ] Université de Lyon, Lyon, France; Department of Nephrology, University Hospital - Lyon Sud, France. Electronic address: denis.fouque@chu-lyon.fr.

[4 ] Université de Lyon, Lyon, France; INSERM UMR 1033, Lyon Cedex 08, France. Electronic address: jean-paul.roux@univ-lyon1.fr.

[5 ] Université de Lyon, Lyon, France; INSERM UMR 1033, Lyon Cedex 08, France. Electronic address: roland.chapurlat@chu-lyon.fr.

[6 ] Laboratory of Pathophysiology, University of Antwerp, Wilrijk, Belgium. Electronic address: patrick.dhaese@uantwerpen.be.

[7 ] Laboratory of Pathophysiology, University of Antwerp, Wilrijk, Belgium. Electronic address: Geert.Behets@uantwerpen.be.

[8 ] KU Leuven, Department of Microbiology and Immunology, Laboratory of Nephrology, Belgium. Electronic address: pieter.evenepoel@uzleuven.be.

[9 ] Columbia University Medical Center, New York, NY, United States. Electronic address: tln2001@cumc.columbia.edu.

[10 ] INSERM U1059 and University Hospital, Saint-Etienne, France; Université de Lyon, Lyon, France. Electronic address: mh.lafage.proust@univ-st-etienne.fr.

Article

Publisher Item ID: S8756-3282(20)30240-4

DOI: 10.1016/j.bone.2020.115460

PubMed ID: 32485361

SO-VID: ba260101-6c91-4bed-b253-d26ed2e4b40a

History

Keywords: Bone biopsy,Small,Renal osteodystrophy,Histomorphometry,Trephine

Data availability:

Keywords: Bone biopsy, Small, Renal osteodystrophy, Histomorphometry, Trephine

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