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      First person – Tylor Lewis

      research-article
      Disease Models & Mechanisms
      The Company of Biologists Ltd

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          Abstract

          First Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping researchers promote themselves alongside their papers. Tylor Lewis is first author on ‘ Microvesicle release from inner segments of healthy photoreceptors is a conserved phenomenon in mammalian species ’, published in DMM. Tylor is a postdoc in the lab of Vadim Arshavsky at Duke University Medical Center, Durham, NC, USA, investigating the biology of the visual system and the pathophysiological mechanisms of retinal disease.

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          Microvesicle release from inner segments of healthy photoreceptors is a conserved phenomenon in mammalian species

          ABSTRACT Many inherited visual diseases arise from mutations that affect the structure and function of photoreceptor cells. In some cases, the pathology is accompanied by a massive release of extracellular vesicles from affected photoreceptors. In this study, we addressed whether vesicular release is an exclusive response to ongoing pathology or a normal homeostatic phenomenon amplified in disease. We analyzed the ultrastructure of normal photoreceptors from both rod- and cone-dominant mammalian species and found that these cells release microvesicles budding from their inner segment compartment. Inner segment-derived microvesicles vary in their content, with some of them containing the visual pigment rhodopsin and others appearing to be interconnected with mitochondria. These data suggest the existence of a fundamental process whereby healthy mammalian photoreceptors release mistrafficked or damaged inner segment material as microvesicles into the interphotoreceptor space. This release may be greatly enhanced under pathological conditions associated with defects in protein targeting and trafficking. This article has an associated First Person interview with the first author of the paper.
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            Author and article information

            Journal
            Dis Model Mech
            Dis Model Mech
            DMM
            Disease Models & Mechanisms
            The Company of Biologists Ltd
            1754-8403
            1754-8411
            1 December 2022
            1 December 2022
            1 December 2022
            : 15
            : 12
            : dmm049984
            Article
            DMM049984
            10.1242/dmm.049984
            10655808
            36420969
            ba42a8df-67ff-4d6d-ba08-033f47011395
            © 2022. Published by The Company of Biologists Ltd

            This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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            First Person

            Molecular medicine
            Molecular medicine

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