Blog
About

11
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      [Epithelioid angiomyolipoma of the kidney--a new tumor entity. Case report on a tumor with many multinucleated giant cells].

      1 , , ,

      Der Pathologe

      Read this article at

      ScienceOpenPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Epithelioid angiomyolipoma is a recently recognized tumor entity, of which 9 tumors are documented in the literature. We report a case that occurred in a 19 years old patient. The tumor consisted of epithelioid cells ranging from medium sized and polygonal to giant cells with prominent nucleoli. Remarkably, there were many multinucleated giant cells. Hemorrhage, necrosis, and clusters of foamy macrophages were also present. Obvious elements of typical angiomyolipoma, especially fatty tissue was not found. Flow cytometry revealed diploid tumor cells with a high S-phase fraction of 9.7%. Melanoma-associated antigen HMB-45 and CD 68 was detected in the epithelioid and spindle cells. The multinucleated giant cells stained for desmin and KP1, and to a lesser extent for HMB-45 and vimentin. There was no expression of cytokeratin or epithelial membrane antigen. Epithelioid angiomyolipoma often pose problems in diagnosis, particularly with regard to distinction from renal cell carcinoma. Previous reports in the literature suggest that epithelioid angiomyolipoma may have malignant potential.

          Related collections

          Author and article information

          Journal
          Pathologe
          Der Pathologe
          0172-8113
          0172-8113
          Nov 1998
          : 19
          : 6
          Affiliations
          [1 ] Institut für Pathologie der Universität Basel.
          Article
          9885008

          Comments

          Comment on this article