Evaluation of angiotensinogen c.1-44G>A and p.M268T variants as risk factors for fibrosis progression in chronic hepatitis C and liver diseases of various etiologies.

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Abstract

Hepatic stellate cells express all components of the renin-angiotensinogen (AGT) system and secrete active angiotensin II. Animal studies provided evidence that angiotensin II stimulates the accumulation of extracellular matrix by enhancing transforming growth factor beta1 production. A functional genetic alteration in the human AGT promoter (c.1-44G>A) has been linked to accelerated progression of fibrosis in hepatitis C virus infection.

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Journal

Journal ID (iso-abbrev): Genet Test Mol Biomarkers

Title: Genetic testing and molecular biomarkers

Publisher: Mary Ann Liebert Inc

ISSN (Electronic): 1945-0257

ISSN (Print): 1945-0257

Publication date (Electronic): Jun 2009

Volume: 13

Issue: 3

Affiliations

[1 ] Medizinische Klinik mit Schwerpunkt Hepatologie und Gastroenterologie, Charité Universitätsmedizin Berlin, Berlin, Germany.

Article

DOI: 10.1089/gtmb.2008.0135

PubMed ID: 19473084

SO-VID: ba863ba6-04c1-467b-bd67-3158c0bba3b1

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