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      SCovNet: A Skip Connection-based Feature Union Deep Learning Technique with Statistical Approach Analysis for the Detection of COVID-19

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          Abstract

          Background and Objective:

          The global population has been heavily impacted by the COVID-19 pandemic of coronavirus. Infections are spreading quickly around the world, and new spikes (Delta, Delta Plus, and Omicron) are still being made. The real-time reverse transcription-polymerase chain reaction (RT-PCR) is the method most often used to find viral RNA in a nasopharyngeal swab. However, these diagnostic approaches require human involvement and consume more time per prediction. Moreover, the existing conventional test mainly suffers from false negatives, so there is a chance for the virus to spread quickly. Therefore, a rapid and early diagnosis of COVID-19 patients is needed to overcome these problems.

          Methods:

          Existing approaches based on deep learning for COVID detection are suffering from unbalanced datasets, poor performance, and gradient vanishing problems. A customized skip connection-based network with a feature union approach has been developed in this work to overcome some of the issues mentioned above. Gradient information from chest X-ray (CXR) images to subsequent layers is bypassed through skip connections. In the script’s title, “SCovNet” refers to a skip-connection-based feature union network for detecting COVID-19 in a short notation. The performance of the proposed model was tested with two publicly available CXR image databases, including balanced and unbalanced datasets.

          Results:

          A modified skip connection-based CNN model was suggested for a small unbalanced dataset (Kaggle) and achieved remarkable performance. In addition, the proposed model was also tested with a large GitHub database of CXR images and obtained an overall best accuracy of 98.67% with an impressive low false-negative rate of 0.0074.

          Conclusions:

          The results of the experiments show that the proposed method works better than current methods at finding early signs of COVID-19. As an additional point of interest, we must mention the innovative hierarchical classification strategy provided for this work, which considered both balanced and unbalanced datasets to get the best COVID-19 identification rate.

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          Most cited references52

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          Is Open Access

          Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR

          Background The ongoing outbreak of the recently emerged novel coronavirus (2019-nCoV) poses a challenge for public health laboratories as virus isolates are unavailable while there is growing evidence that the outbreak is more widespread than initially thought, and international spread through travellers does already occur. Aim We aimed to develop and deploy robust diagnostic methodology for use in public health laboratory settings without having virus material available. Methods Here we present a validated diagnostic workflow for 2019-nCoV, its design relying on close genetic relatedness of 2019-nCoV with SARS coronavirus, making use of synthetic nucleic acid technology. Results The workflow reliably detects 2019-nCoV, and further discriminates 2019-nCoV from SARS-CoV. Through coordination between academic and public laboratories, we confirmed assay exclusivity based on 297 original clinical specimens containing a full spectrum of human respiratory viruses. Control material is made available through European Virus Archive – Global (EVAg), a European Union infrastructure project. Conclusion The present study demonstrates the enormous response capacity achieved through coordination of academic and public laboratories in national and European research networks.
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            Detection of SARS-CoV-2 in Different Types of Clinical Specimens

            This study describes results of PCR and viral RNA testing for SARS-CoV-2 in bronchoalveolar fluid, sputum, feces, blood, and urine specimens from patients with COVID-19 infection in China to identify possible means of non-respiratory transmission.
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              A survey on deep learning in medical image analysis

              Deep learning algorithms, in particular convolutional networks, have rapidly become a methodology of choice for analyzing medical images. This paper reviews the major deep learning concepts pertinent to medical image analysis and summarizes over 300 contributions to the field, most of which appeared in the last year. We survey the use of deep learning for image classification, object detection, segmentation, registration, and other tasks. Concise overviews are provided of studies per application area: neuro, retinal, pulmonary, digital pathology, breast, cardiac, abdominal, musculoskeletal. We end with a summary of the current state-of-the-art, a critical discussion of open challenges and directions for future research.
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                Author and article information

                Journal
                Biocybern Biomed Eng
                Biocybern Biomed Eng
                Biocybernetics and Biomedical Engineering
                Nalecz Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences. Published by Elsevier B.V.
                0208-5216
                2391-467X
                15 February 2023
                15 February 2023
                Affiliations
                [a ]Department of ECE, Aditya Institute of Technology and Management, Tekkali, AP-532201, India
                [b ]Department of EC, National Institute of Technology Rourkela, Odisha-769008, India
                [c ]Information Technology Dept., Faculty of Computers and Information, Menoufia University, Menoufia, Egypt
                [d ]AGH University of Science and Technology, Department of Biocybernetics and Biomedical Engineering, Krakow, Poland
                [e ]Department of Computer Science, Faculty of Computer Science and Telecommunications, Cracow University of Technology, Warszawska 24, 31-155 Krakow, Poland
                [f ]Institute of Theoretical and Applied Informatics, Polish Academy of Sciences, Bałtycka 5, 44-100 Gliwice, Poland
                Article
                S0208-5216(23)00005-0
                10.1016/j.bbe.2023.01.005
                9928742
                36819118
                bb799acd-d1f4-44f6-807e-cf0ffacd333d
                © 2023 Nalecz Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences. Published by Elsevier B.V. All rights reserved.

                Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

                History
                : 25 October 2022
                : 21 December 2022
                : 30 January 2023
                Categories
                Original Research Article

                covid-19,cnn,deep learning,image augmentation,skip connection,x-ray images

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