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      Correlation between Contrast Sensitivity and Visual Acuity in Retinitis pigmentosa Patients

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          Purpose: High-contrast figures such as Landolt rings are insufficient to evaluate the function of the foveal cones of retinitis pigmentosa (RP) patients. We investigated the correlation between visual function as determined with Landolt rings and with the Vistech Contrast Sensitivity Function Test (VCTS) at various spatial frequencies, in addition to the Cambridge Low Contrast Grating (CLCG). Methods: The study included 30 retinitis pigmentosa patients (53 eyes). All patients were assessed with Landolt rings, the Vistech method, and the CLCG. We estimated the relative contribution of contrast sensitivity to visual acuity by VCTS at each spatial frequency and by CLCG by simple linear regression analysis. Results: The results of the regression analysis of VCTS at 1.5, 3.0, and 6.0 cycles/degree showed a significant correlation between Landolt rings and VCTS and between CLCG and VCTS that was strongest at 6.0 cycles/degree. There was no significant correlation between Landolt rings and VCTS or between CLCG and VCTS at 12.0 and 18.0 cycles/degree. Patients with a visual acuity of 20/25 and CLCG greater than 100 were divided into two groups according to their contrast sensitivity at 18.0 cycles/degree on VCTS. Conclusions: The VCTS at the highest frequency was useful for evaluating the foveal visual function in RP patients having good visual acuity with the Landolt rings. Thus, contrast sensitivity should be useful in detecting minute impairment or improvement of visual function in RP.

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          Progression of Visual Field Loss in Patients with Retinitis pigmentosa of Sporadic and Autosomal Recessive Types

          Purpose: We examined the natural course of patients with retinitis pigmentosa of the eight sporadic and five autosomal recessive forms over 5 years. Methods: We measured the areas of the visual fields by Goldmann perimetry using a digitizer and a computer software. Results: The visual field of V-4 isopters in 4 sporadic cases was approximately 200 cm 2 during 30 years after the initial examination, but decreased down to 40 cm 2 in the next 10 years. The visual field was reduced to half the normal field in 3 autosomal recessive cases early below the age of 25 years. In 4 sporadic and 2 autosomal recessive cases, the inferior temporal visual field was the widest at the onset of the disease, but exhibited the most severe loss. The superior nasal area was the narrowest initially, and showed the mildest progression. Conclusions: The visual field in retinitis pigmentosa is constricted age-dependently with severe loss of the inferior temporal visual area and mild damage to the superior nasal area.

            Author and article information

            S. Karger AG
            June 2002
            12 June 2002
            : 216
            : 3
            : 185-191
            aDepartment of Ophthalmology, Takasaki National Hospital, Gunma, and bDepartment of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
            59627 Ophthalmologica 2002;216:185–191
            © 2002 S. Karger AG, Basel

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            Page count
            Figures: 2, Tables: 4, References: 24, Pages: 7
            Original Paper · Travail original · Originalarbeit


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