Toll-like receptor 4 variant D299G induces features of neoplastic progression in Caco-2 intestinal cells and is associated with advanced human colon cancer.

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Abstract

The Toll-like receptor (TLR) 4 mediates homeostasis of the intestinal epithelial cell (IEC) barrier. We investigated the effects of TLR4-D299G on IEC functions.

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Journal

Journal ID (iso-abbrev): Gastroenterology

Title: Gastroenterology

Publisher: Elsevier BV

ISSN (Electronic): 1528-0012

ISSN (Print): 0016-5085

Publication date (Electronic): Dec 2011

Volume: 141

Issue: 6

Affiliations

[1 ] Division of Gastroenterology & Hepatology, University Hospital of Essen, Medical School, University of Duisburg-Essen, Essen, Germany.

Article

Publisher Item ID: S0016-5085(11)01226-1 Mid ID: NIHMS325422

DOI: 10.1053/j.gastro.2011.08.043

PMC ID: 3268964

PubMed ID: 21920464

SO-VID: bd193aaf-2f22-4973-81b9-fbda3dda89ac

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