Contributors
Brian M. Balog: Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
Project administrationRole: ValidationRole: Writing – original draftRole: Writing
– review & editing
Abhilasha Tangada: Role: Formal analysisRole: InvestigationRole: MethodologyRole: Project administrationRole:
Writing – original draftRole: Writing – review & editing
Pooja Sheth: Role: Data curationRole: Formal analysis
Qi-Xiang Song: Role: InvestigationRole: MethodologyRole: Project administrationRole: Writing – original
draftRole: Writing – review & editing
Bruna M. Couri: Role: MethodologyRole: Project administrationRole: Writing – original draftRole: Writing
– review & editing
Leah L. Porras: Role: Project administrationRole: ResourcesRole: Writing – review & editing
Gary G. Deng: Role: Project administrationRole: ResourcesRole: Writing – review & editing
Margot S. Damaser:
ORCID: http://orcid.org/0000-0003-4743-9283
Role: Formal analysisRole: MethodologyRole: Project administrationRole: SupervisionRole:
Writing – original draftRole: Writing – review & editing
Michael Bader: Role: Editor
Journal
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
28
August
2019
Publication date Collection: 2019
Volume: 14
Issue: 8
Electronic Location Identifier: e0220788
Affiliations
[1
]
Department of Biomedical Engineering, Lerner Research Institute, the Cleveland Clinic,
Cleveland, Ohio, United States of America
[2
]
Advanced Platform Technology Center, Louis Stokes Cleveland Veterans Affairs Medical
Center, Cleveland, Ohio, United States of America
[3
]
Department of Biology, University of Akron, Akron, Ohio, United States of America
[4
]
Department of Urology, Changhai Hospital, Naval Medical University, Shanghai, People’s
Republic of China
[5
]
Department of Obstetrics and Gynecology, the Cleveland Clinic, Cleveland, Ohio, United
States of America
[6
]
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, United
States of America
[7
]
Glickman Urological and Kidney Institute, the Cleveland Clinic, Cleveland, Ohio, United
States of America
Max Delbruck Centrum fur Molekulare Medizin Berlin Buch, GERMANY
Author notes
Competing Interests: I have read the journal’s policy and the authors of this manuscript have the following
competing interests: LLP is an employee of Eli Lilly. GGD is an employee of Eli Lilly.
MSD was principal investigator of a sponsored research agreement with Eli Lilly at
the Cleveland Clinic. The funder provided support in the form of salaries for the
authors LLP and GGD, but did not have any additional role in the data collection and
analysis, decision to publish, or preparation of the manuscript. This does not alter
our adherence to PLOS ONE policies on sharing data and materials.
Author information
Article
Publisher ID:
PONE-D-19-06317
DOI: 10.1371/journal.pone.0220788
PMC ID: 6713339
PubMed ID: 31461445
SO-VID: bd337f61-25cf-470e-a1f7-b31c26e7fd5c
License:
This is an open access article, free of all copyright, and may be freely reproduced,
distributed, transmitted, modified, built upon, or otherwise used by anyone for any
lawful purpose. The work is made available under the
Creative Commons CC0 public domain dedication.
History
Date
received
: 4
March
2019
Date
accepted
: 23
July
2019
Page count
Figures: 5,
Tables: 2,
Pages: 15
Funding
This work was done with a sponsored research agreement to the Cleveland Clinic from
Eli Lilly (P.I. MSD). The funder provided support in the form of salaries for authors
LLP and GGD, but did not have any additional role in the study design, data collection
and analysis, decision to publish, or preparation of the manuscript. The specific
roles of these authors are articulated in the ‘author contributions’ section. Eli
Lilly employees participated in study design and preparation of manuscript, but final
decisions were made by Dr. Damaser and her group at the Cleveland Clinic. Data collection
and analysis was done solely by Dr. Damaser and her group. Additional support from
the Cleveland Clinic and the U.S. Department of Veterans Affairs was provided.
Categories
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Renal System
Subject:
Bladder
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Renal System
Subject:
Bladder
Subject:
Biology and Life Sciences
Subject:
Bioengineering
Subject:
Biotechnology
Subject:
Medical Devices and Equipment
Subject:
Catheters
Subject:
Engineering and Technology
Subject:
Bioengineering
Subject:
Biotechnology
Subject:
Medical Devices and Equipment
Subject:
Catheters
Subject:
Medicine and Health Sciences
Subject:
Medical Devices and Equipment
Subject:
Catheters
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Musculoskeletal System
Subject:
Muscles
Subject:
Smooth Muscles
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Musculoskeletal System
Subject:
Muscles
Subject:
Smooth Muscles
Subject:
Biology and Life Sciences
Subject:
Developmental Biology
Subject:
Fibrosis
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Enzymology
Subject:
Enzymes
Subject:
Phosphodiesterases
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Enzymes
Subject:
Phosphodiesterases
Subject:
Medicine and Health Sciences
Subject:
Euthanasia
Subject:
Medicine and Health Sciences
Subject:
Urology
Subject:
Bladder and Ureteric Disorders
Subject:
Cystitis
Subject:
Biology and Life Sciences
Subject:
Bioengineering
Subject:
Biotechnology
Subject:
Medical Devices and Equipment
Subject:
Medical Implants
Subject:
Engineering and Technology
Subject:
Bioengineering
Subject:
Biotechnology
Subject:
Medical Devices and Equipment
Subject:
Medical Implants
Subject:
Medicine and Health Sciences
Subject:
Medical Devices and Equipment
Subject:
Medical Implants
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