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      MMP-7 and MMP-9 are overexpressed in the synovial tissue from severe temporomandibular joint dysfunction

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          Abstract

          Matrix metalloproteinases (MMPs) are tissue-enzymes that play a key role during the remodeling process, such as in inflammatory diseases. MMP-7 and MMP-9 have been shown to be implicated in extracellular matrix homeostasis and in joint disc remodeling. The objective of this study was to determine the relation of MMP-7 and MMP-9 expression with severe temporomandibular joint dysfunction, in particular with anterior disk displacement without reduction (ADDwoR), using an immunohistochemical approach. Therefore, twenty human temporomandibular synovia in the test group and ten in the control group were collected. The results showed there was a statistically significant difference (P<0.001) for morphometric and densitometric analysis of both detected MMPs in control and test groups. In conclusion, MMP-7 and MMP-9 were overexpressed in the synovial tissue of patients with ADDwoR.

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          Matrix metalloproteinases.

          H. Nagase, J F WOESSNER (1999)
          Article 0 comments Cited 382 times – based on 0 reviews     Review now
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            Expression profiling of metalloproteinases and their inhibitors in synovium and cartilage

            Rose Davidson, Jasmine Waters, Lara Kevorkian … (2006)
            Cartilage destruction in osteoarthritis (OA) is thought to be mediated by two main enzyme families; the matrix metalloproteinases (MMPs) are responsible for cartilage collagen breakdown, whereas enzymes from the 'a disintegrin and metalloproteinase domain with thrombospondin motifs' (ADAMTS) family mediate cartilage aggrecan loss. Tissue inhibitors of metalloproteinases (TIMPs) regulate the activity of these enzymes. Although cartilage destruction in OA might be driven by the chondrocyte, low-grade synovitis is reported in patients with all grades of this disease. Our earlier work profiling these gene families in cartilage identified a number of genes that are regulated in OA, which are hence implicated in the disease process. Because the synovium might contribute to cartilage-matrix destruction in OA, we have extended the screening in the current study. We have profiled MMP, ADAMTS and TIMP genes in both cartilage and synovium from patients with either OA of the hip or a fracture to the neck of femur (NOF), giving a more complete picture of proteolysis in this disease. The four most significantly upregulated genes (P < 0.0001) in OA synovium compared to the fractured NOF are MMP28, ADAMTS16, ADAMTS17 and TIMP2. For MMP9, MMP10, MMP12, MMP17, MMP23, MMP28, ADAMTS4, and ADAMTS9, there is a significant correlation between expression levels in the synovium and cartilage, suggesting similar mechanisms of regulation. Additionally, we have shown that in cartilage the median level of steady-state mRNA for MMP13 is approximately 20-fold higher than MMP28 and approximately 1,500-fold higher than ADAMTS16, with expression of this latter gene approximately 150-fold higher in synovium than cartilage. This study is the most comprehensive analysis of the metzincin family of proteinases in the joint to date and has identified several proteinase genes not previously reported to be expressed or regulated in synovium.
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              3D osteoarthritic changes in TMJ condylar morphology correlates with specific systemic and local biomarkers of disease.

              J Sugai, W Giannobile, B Paniagua … (2014)
              To assess 3D morphological variations and local and systemic biomarker profiles in subjects with a diagnosis of temporomandibular joint osteoarthritis (TMJ OA).
              Article 0 comments Cited 27 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Eur J Histochem
                Journal ID (publisher-id): IJA
                Title: European Journal of Histochemistry : EJH
                Publisher: PAGEPress Publications, Pavia, Italy
                ISSN (Print): 1121-760X
                ISSN (Electronic): 2038-8306
                Publication date (Electronic): 16 April 2020
                Publication date Collection: 26 March 2020
                Volume: 64
                Issue: 2
                Electronic Location Identifier: 3113
                Affiliations
                [1 ]Department of Biomedical and Biotechnological Sciences, Section of Anatomy, University of Catania , Italy
                [2 ]School of Dentistry, Marquette University , Milwaukee, WI, USA
                [3 ]Department of Orthodontics, School of Dentistry, University of Catania , Italy
                [4 ]Department of Orthodontics, School of Dentistry, Catholic University of the Sacred Heart , Rome, Italy
                Author notes
                Department BIOMETEC, Section of Anatomy, University of Catania, via S. Sofia 87, 95123 Catania, Italy. verofiletti@ 123456gmail.com

                Contributions: CL, LR, contribution to design experiments and data acquisition, manuscript drafting; GRMLR, LGA, contribution to study design and data acquisition; VF, LEA, CG, contribution to study design, manuscript critical revision. All authors read and approved the final manuscript.

                Conflict of interest: The authors report no conflicts of interest related to this study.

                Ethics approval and consent to participate: The Ethics Committee of the Pontifical Catholic University of Paranà, according to Resolution 196/96 of the National Health Council (registration number 104), approved the study.

                Patient consent for publication: Not applicable.

                Informed consent: Patients’ informed consent had been obtained before tissue collection.

                Article
                DOI: 10.4081/ejh.2020.3113
                PMC ID: 7171425
                PubMed ID: 32312031
                SO-VID: bda26da1-dc72-4bf6-80c8-dc483e8d9df0
                Copyright © ©Copyright: the Author(s)
                License:

                This article is distributed under the terms of the Creative Commons Attribution Noncommercial License ( by-nc 4.0) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

                History
                Date received : 23 January 2020
                Date accepted : 27 March 2020
                Page count
                Figures: 2, Tables: 0, Equations: 0, References: 35, Pages: 5
                Categories
                Subject: Article

                ScienceOpen disciplines: Clinical chemistry
                Keywords: mmp-7,mmp-9,tmj synovial,tmj dysfunction
                Data availability:
                ScienceOpen disciplines: Clinical chemistry
                Keywords: mmp-7, mmp-9, tmj synovial, tmj dysfunction

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