Contributors
Lilia Turcios: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole:
MethodologyRole: ValidationRole: Writing – original draftRole: Writing – review &
editing
Eduardo Chacon: Role: Data curationRole: ValidationRole: Writing – original draftRole: Writing – review
& editing
Catherine Garcia: Role: Data curationRole: ValidationRole: Writing – review & editing
Pedro Eman:
ORCID: http://orcid.org/0000-0001-6236-1723
Role: Data curationRole: ValidationRole: Writing – original draftRole: Writing – review
& editing
Virgilius Cornea: Role: MethodologyRole: Resources
Jieyun Jiang: Role: ConceptualizationRole: ValidationRole: Writing – review & editing
Brett Spear: Role: ConceptualizationRole: ValidationRole: Writing – review & editing
Chunming Liu: Role: ConceptualizationRole: ValidationRole: Writing – review & editing
David S. Watt: Role: ConceptualizationRole: ValidationRole: Writing – review & editing
Francesc Marti: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole:
MethodologyRole: SupervisionRole: ValidationRole: Writing – original draftRole: Writing
– review & editing
Roberto Gedaly:
ORCID: http://orcid.org/0000-0003-4958-0918
Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole:
MethodologyRole: Project administrationRole: SupervisionRole: ValidationRole: Writing
– original draftRole: Writing – review & editing
Masaru Katoh: Role: Editor
Journal
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
22
February
2019
Publication date Collection: 2019
Volume: 14
Issue: 2
Electronic Location Identifier: e0212538
Affiliations
[1
]
Department of Surgery, Transplant Center, College of Medicine, University of Kentucky,
Lexington, Kentucky, United States of America
[2
]
Lucille Parker Markey Cancer Center, University of Kentucky, Lexington, Kentucky,
United States of America
[3
]
Department of Microbiology, Immunology & Molecular Genetics, College of Medicine,
University of Kentucky, Lexington, Kentucky, United States of America
[4
]
Department of Molecular and Cellular Biochemistry, College of Medicine, University
of Kentucky, Lexington, Kentucky, United States of America
[5
]
Center for Pharmaceutical Research and Innovation, College of Pharmacy, University
of Kentucky, Lexington, Kentucky, United States of America
National Cancer Center, JAPAN
Author notes
Competing Interests: CL and DSW have partial ownership in a private venture, Epionc, Inc., incorporated
to develop small-molecule inhibitors for cancer treatment through a licensing agreement
with the University of Kentucky. In accord with University of Kentucky policies, CL
and DSW disclosed prior work to the University of Kentucky’s Intellectual Property
Committee and complied with stipulations of the University’s Conflict of Interest
Oversight Committee. Epionc, Inc., has no license for compounds described in this
paper. This does not alter our adherence to PLOS ONE policies on sharing data and
materials.
Author information
Article
Publisher ID:
PONE-D-18-28097
DOI: 10.1371/journal.pone.0212538
PMC ID: 6386480
PubMed ID: 30794613
SO-VID: bfed1613-dade-4c7c-9010-d1f07ac6a9fe
Copyright © © 2019 Turcios et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
History
Date
received
: 26
September
2018
Date
accepted
: 5
February
2019
Page count
Figures: 11,
Tables: 0,
Pages: 17
Funding
This research was supported by the Biospecimen Procurement and Translational Pathology
Shared Resource Facility of the University of Kentucky Markey Cancer Center (P30CA177558).
The research was also supported by the Redox Metabolism Shared Resource Facility of
the University of Kentucky Markey Cancer Center (P30CA177558). The funders had no
role in study design, data collection and analysis, decision to publish, or preparation
of the manuscript.
Categories
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cell Processes
Subject:
Cell Death
Subject:
Autophagic Cell Death
Subject:
Medicine and Health Sciences
Subject:
Oncology
Subject:
Cancers and Neoplasms
Subject:
Carcinomas
Subject:
Hepatocellular Carcinoma
Subject:
Medicine and Health Sciences
Subject:
Oncology
Subject:
Cancers and Neoplasms
Subject:
Gastrointestinal Tumors
Subject:
Hepatocellular Carcinoma
Subject:
Medicine and Health Sciences
Subject:
Gastroenterology and Hepatology
Subject:
Liver Diseases
Subject:
Hepatocellular Carcinoma
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cell Processes
Subject:
Cell Death
Subject:
Apoptosis
Subject:
Medicine and Health Sciences
Subject:
Oncology
Subject:
Cancer Treatment
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Bioenergetics
Subject:
Energy-Producing Organelles
Subject:
Mitochondria
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Structures and Organelles
Subject:
Energy-Producing Organelles
Subject:
Mitochondria
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cell Processes
Subject:
Cell Proliferation
Subject:
Research and Analysis Methods
Subject:
Spectrum Analysis Techniques
Subject:
Spectrophotometry
Subject:
Cytophotometry
Subject:
Flow Cytometry
Subject:
Research and Analysis Methods
Subject:
Specimen Preparation and Treatment
Subject:
Staining
Subject:
Cell Staining
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