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      Impact of the Daily Blood Pressure Load on the Development of Hypertensive Heart Disease

      Cardiology

      S. Karger AG

      Blood pressure load, Ambulatory blood pressure, Lisinopril, Left ventricular filling

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          Abstract

          Blood pressure (BP) load is a method of data analysis for 24-hour BP recordings that calculates the percentage of elevated pressures above a defined threshold value. This paper reviews the relevance of BP load to indexes of hypertensive target organ disease and the usefulness of the load in assessing anti-hypertensive therapy. Studies that have assessed the range of BP load and the associations between the load and indexes of hypertensive target organ disease in untreated subjects were included in this review. Additional data from a therapeutic trial have been newly evaluated to assess the effects of lisinopril monotherapy on systolic and diastolic BP load in 30 mild-to-moderately hypertensive patients. BP load, whether taken as a percentage of elevated pressures over the day and night, or as integrated areas under the BP curve, predicts pathological indexes of hypertensive heart disease. In the therapeutic evaluation of BP load, lisinopril reduced systolic BP load from 75 to 44% (p < 0.001) and diastolic BP load from 56 to 29% (p < 0.001). The data have shown a close relationship between BP load and indexes of hypertensive disease. This finding and the ease of use in clinical therapeutic trials suggest that BP load reduction is a worthwhile parameter to follow in studies of antihypertensive drugs.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1992
          1992
          14 November 2008
          : 81
          : 4-5
          : 299-306
          Affiliations
          Section of Hypertension and Vascular Diseases, Department of Medicine, University of Connecticut School of Medicine, Farmington, Conn., USA
          Article
          175820 Cardiology 1992;81:299–306
          10.1159/000175820
          1301258
          © 1992 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 8
          Categories
          LVH – A Suitable Case for Treatment

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