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      1,25-Dihydroxyvitamin D 3 Target Cells in Rat Mammary Gland

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          Abstract

          In autoradiograms of mammary glands of rats on days 18 and 20 of pregnancy and day 6 of lactation after injection of <sup>3</sup>H 1,25-(OH)<sub>2</sub> vitamin D<sub>3</sub>, a nuclear concentration of radioactivity is observed in alveolar and ductal cells, as well as in cells of the epidermis of the nipple. Myoepithelial cells and connective tissue cells do not concentrate the hormone in their nuclei. The nuclear radioactivity appears specific, since 1,25-(OH)<sub>2 </sub>vitamin D<sub>3</sub> but not 25-(OH)2 vitamin D<sub>3</sub> prevents the uptake. The results suggest the existence of nuclear receptors for 1,25-(OH)2 vitamin D3 in mammary tissues and thus complements previous biochemical evidence showing the presence of cytoplasmic receptors for the hormone in mouse mammary glands; in addition, our results allow the identification of the cell types possessing the receptors.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1981
          1981
          25 November 2008
          : 15
          : 4
          : 263-269
          Affiliations
          aDepartment of Anatomy, University of Ottawa, Ottawa, Ont., Canada; bDepartments of Anatomy and Pharmacology, University of North Carolina, Chapel Hill, N.C., USA; cDepartment of Biochemistry, University of Wisconsin, Madison, Wisc., USA
          Article
          179465 Horm Res 1981;15:263–269
          10.1159/000179465
          6100940
          © 1981 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 7
          Categories
          Original Paper

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