Acupoint laterality is defined as the non-equivalence effect and the diversity of intermediate links resulted from stimulating isonym acupoints on the different side respectively. This kind of study is the important supplement to acupoint specificity and can provide the basis for acupoint selection in clinical practice. On the other side, acupoints relevance deduced by acupoint laterality (symmetry/symmetry breaking) can be reference for acupoint diagnosis and the changes of acupuncture treatment model in clinic.