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Genomic surveillance of SARS-CoV-2 in Thailand reveals mixed imported populations, a local lineage expansion and a virus with truncated ORF7a
Preprint
Elizabeth M Batty ,
Theerarat Kochakarn ,
Bhakbhoom Panthan ,
Krittikorn Kumpornsin ,
Poramate Jiaranai ,
Arporn Wangwiwatsin ,
Namfon Kotanan ,
Peera Jaruampornpan ,
Treewat Watthanachockchai ,
Kingkan Rakmanee ,
Insee Sensorn ,
Somnuek Sungkanuparph ,
Ekawat Pasomsub ,
Thanat Chookajorn ,
Wasun Chantratita
May 25 2020
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Abstract
Coronavirus Disease 2019 (COVID-19) is a global public health threat. Genomic surveillance of SARS-CoV-2 was implemented during March 2020 at a major diagnostic hub in Bangkok, Thailand. Several virus lineages supposedly originated in many countries were found, and a Thai-specific lineage, designated A/Thai-1, has expanded to be predominant in Thailand. A virus sample in the SARS-CoV-2 A/Thai-1 lineage contains a frame-shift deletion at ORF7a, encoding a putative host antagonizing factor of the virus.