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      Subconjunctival Injection of Low Doses of Mitomycin C: Effects on Fibroblast Proliferation

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          Abstract

          We evaluated the effect of low doses of mitomycin C (MMC) in subconjunctival injection on fibroblast viability. Eighteen rabbits received subconjunctival injections: group 1 was injected with balanced salt solution (BSS), group 2 received MMC 0.025 mg, and group 3 MMC 0.005 mg. Tissue samples were taken 1 h after the injection (conjunctiva, sclera and cornea at 0 and 90 °) and cultured. The average scleral and conjunctival outgrowth in the MMC-treated groups was significantly inferior to the outgrowth of the samples treated with BSS. Subconjunctival injections of MMC (0.025 and 0.005 mg) have an inhibitory effect on conjunctiva at 0 ° and on scleral fibroblast populations.

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          Ocular hypotensive effects of PhXA41 in glaucoma patients and IOP change during day and night in normal volunteers

          H. Mishima (1995)
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            Author and article information

            Journal
            OPH
            Ophthalmologica
            10.1159/issn.0030-3755
            Ophthalmologica
            S. Karger AG
            0030-3755
            1423-0267
            1998
            October 1998
            12 August 1998
            : 212
            : 5
            : 306-309
            Affiliations
            Department of Ophthalmology, Miguel Servet Hospital, Zaragoza, Spain
            Article
            27313 Ophthalmologica 1998;212:306–309
            10.1159/000027313
            9693286
            c4003ce3-c265-4ee2-b83a-6b7933432f3b
            © 1998 S. Karger AG, Basel

            Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

            History
            Page count
            Pages: 4
            Categories
            Original Paper · Travail original · Originalarbeit

            Vision sciences,Ophthalmology & Optometry,Pathology
            Fibroblasts,Rabbit,Culture cells,Mitomycin C,Antiproliferative agents

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