Effect of antiretroviral therapy on hemoglobin A2 values can have implications in antenatal beta-thalassemia screening programs.

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Abstract

Raised hemoglobin-A2 (HbA2) is the diagnostic hallmark of beta-thalassemia trait (βTT). Diagnostic difficulties may arise in HIV-positive patients on antiretroviral therapy (ART). We compared the effect of various antiretroviral drugs on HbA2 levels. We attempted to determine which drugs elevate HbA2 levels causing a false-positive diagnosis of βTT and correlate the findings with red cell indices.

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Author and article information

Journal

Journal ID (iso-abbrev): Infect Dis (Lond)

Title: Infectious diseases (London, England)

Publisher: Informa Healthcare

ISSN (Electronic): 2374-4243

ISSN (Print): 2374-4243

Publication date (Electronic): Feb 2016

Volume: 48

Issue: 2

Affiliations

[1 ] a Department of Hematology , Postgraduate Institute of Medical Education and Research , Chandigarh , India.

[2 ] b Center of Excellence in HIV Care, Postgraduate Institute of Medical Education and Research , Chandigarh , India.

[3 ] c Department of Internal Medicine , Postgraduate Institute of Medical Education and Research , Chandigarh , India.

Article

DOI: 10.3109/23744235.2015.1089592

PubMed ID: 26431373

SO-VID: c42d6cd5-d0fa-47bc-87de-f774ffe5fca6

History

Keywords: HIV,HbA2, antiretroviral treatment,stavudine,tenofovir,zidovudine

Data availability:

Keywords: HIV, HbA2, antiretroviral treatment, stavudine, tenofovir, zidovudine

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