The same oxygenation-state introduction of hypervalent sulfur under transition-metal-free conditions

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Abstract

This review discusses the application of the same oxygenation-state introduction of hypervalent sulfur strategy under transition-metal-free conditions.

Abstract

Sulfonyl compounds have attracted considerable interest due to their extensive applications in drug discovery. Access to the assembly of SO ₂-containing compounds viathe oxygenation oxidative-state introduction of hypervalent sulfur has come to the fore in recent years. This review discusses the application of the same oxygenation-state introduction of hypervalent sulfur strategy under transition-metal-free conditions, and presents it in light of different atoms being linked to the sulfonyl group, including sulfones, sulfonamides, sulfonyl fluorides and thiosulfonates.

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Minghao Feng, Bingqing Tang, Steven Liang … (2016)

The impact of the development of sulfur therapeutics is instrumental to the evolution of the pharmaceutical industry. Sulfur-derived functional groups can be found in a broad range of pharmaceuticals and natural products. For centuries, sulfur continues to maintain its status as the dominating heteroatom integrated into a set of 362 sulfur-containing FDA approved drugs (besides oxygen or nitrogen) through the present. Sulfonamides, thioethers, sulfones and Penicillin are the most common scaffolds in sulfur containing drugs, which are well studied both on synthesis and application during the past decades. In this review, these four moieties in pharmaceuticals and recent advances in the synthesis of the corresponding core scaffolds are presented.